Biological basis of depression in adults with diabetes

Shivam Champaneri; Gary S. Wand; Saurabh S. Malhotra; Sarah S. Casagrande; Sherita Hill Golden

doi:10.1007/s11892-010-0148-9

Biological basis of depression in adults with diabetes

Shivam Champaneri, Gary S. Wand, Saurabh S. Malhotra, Sarah S. Casagrande, Sherita Hill Golden

School of Medicine

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

Original language	English (US)
Pages (from-to)	396-405
Number of pages	10
Journal	Current diabetes reports
Volume	10
Issue number	6
DOIs	https://doi.org/10.1007/s11892-010-0148-9
State	Published - Dec 2010

Keywords

Adipocytokines
Awakening cortisol
C-reactive protein (CRP)
Catecholamines
Cortisol
Cortisol awakening response
Cytokines
Depression
Diabetes
Diurnal cortisol
Heart rate variability
Hypothalamic-pituitary-adrenal (HPA) axis
Inflammation
Inflammatory markers
Insulin resistance
Interleukin-6 (IL-6)
Metabolic syndrome
Obesity
Sympathetic nervous system
Type 2 diabetes
Visceral fat

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/s11892-010-0148-9

Cite this

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title = "Biological basis of depression in adults with diabetes",

abstract = "Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.",

keywords = "Adipocytokines, Awakening cortisol, C-reactive protein (CRP), Catecholamines, Cortisol, Cortisol awakening response, Cytokines, Depression, Diabetes, Diurnal cortisol, Heart rate variability, Hypothalamic-pituitary-adrenal (HPA) axis, Inflammation, Inflammatory markers, Insulin resistance, Interleukin-6 (IL-6), Metabolic syndrome, Obesity, Sympathetic nervous system, Type 2 diabetes, Visceral fat",

author = "Shivam Champaneri and Wand, {Gary S.} and Malhotra, {Saurabh S.} and Casagrande, {Sarah S.} and Golden, {Sherita Hill}",

note = "Funding Information: Acknowledgments Dr. Golden was supported by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases (5K23 DK071565). Dr. Champaneri was supported by a training grant (T32 Ruth L. Kirschstein National Research Service Award). This research was supported by the Johns Hopkins University School of Medicine General Clinical Research Grant grant number M01-RR00052, from the National Center for Research Resources/National Institutes of Health and the Johns Hopkins Prevention and Control Core of the Diabetes Research and Training Center from the National Institutes of Diabetes, Digestive, and Kidney Diseases grant number P60 DK079637. We thank Dr. Mark Punyanitya for performing visceral fat measurements and our research coordinator, Ms. Bennette Drummond-Watts, for her excellent recruitment and study coordination skills.",

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doi = "10.1007/s11892-010-0148-9",

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volume = "10",

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AU - Champaneri, Shivam

AU - Wand, Gary S.

AU - Malhotra, Saurabh S.

AU - Casagrande, Sarah S.

AU - Golden, Sherita Hill

N1 - Funding Information: Acknowledgments Dr. Golden was supported by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases (5K23 DK071565). Dr. Champaneri was supported by a training grant (T32 Ruth L. Kirschstein National Research Service Award). This research was supported by the Johns Hopkins University School of Medicine General Clinical Research Grant grant number M01-RR00052, from the National Center for Research Resources/National Institutes of Health and the Johns Hopkins Prevention and Control Core of the Diabetes Research and Training Center from the National Institutes of Diabetes, Digestive, and Kidney Diseases grant number P60 DK079637. We thank Dr. Mark Punyanitya for performing visceral fat measurements and our research coordinator, Ms. Bennette Drummond-Watts, for her excellent recruitment and study coordination skills.

PY - 2010/12

Y1 - 2010/12

N2 - Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

AB - Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

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JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

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ER -

Biological basis of depression in adults with diabetes

Abstract

Keywords

ASJC Scopus subject areas

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