Biological basis of depression in adults with diabetes

Shivam Champaneri; Gary S. Wand; Saurabh S. Malhotra; Sarah S. Casagrande; Sherita Hill Golden

doi:10.1007/s11892-010-0148-9

Biological basis of depression in adults with diabetes

Shivam Champaneri, Gary S. Wand, Saurabh S. Malhotra, Sarah S. Casagrande, Sherita Hill Golden

School of Medicine

Research output: Contribution to journal › Review article

Abstract

Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

Original language	English (US)
Pages (from-to)	396-405
Number of pages	10
Journal	Current diabetes reports
Volume	10
Issue number	6
DOIs	https://doi.org/10.1007/s11892-010-0148-9
State	Published - Dec 1 2010

Keywords

Adipocytokines
Awakening cortisol
C-reactive protein (CRP)
Catecholamines
Cortisol
Cortisol awakening response
Cytokines
Depression
Diabetes
Diurnal cortisol
Heart rate variability
Hypothalamic-pituitary-adrenal (HPA) axis
Inflammation
Inflammatory markers
Insulin resistance
Interleukin-6 (IL-6)
Metabolic syndrome
Obesity
Sympathetic nervous system
Type 2 diabetes
Visceral fat

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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Champaneri, S., Wand, G. S., Malhotra, S. S., Casagrande, S. S., & Golden, S. H. (2010). Biological basis of depression in adults with diabetes. Current diabetes reports, 10(6), 396-405. https://doi.org/10.1007/s11892-010-0148-9

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abstract = "Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.",

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AU - Golden, Sherita Hill

PY - 2010/12/1

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N2 - Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

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