TY - JOUR
T1 - Biological activity of a mouse-human chimeric immunoglobulin G2 antibody to Cryptococcus neoformans polysaccharide
AU - Kwon, Katherine Westin
AU - Lendvai, Nikoletta
AU - Morrison, Sherie
AU - Trinh, K. Ryan
AU - Casadevall, Arturo
PY - 2002
Y1 - 2002
N2 - The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.
AB - The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036148182&partnerID=8YFLogxK
U2 - 10.1128/CDLI.9.1.201-204.2002
DO - 10.1128/CDLI.9.1.201-204.2002
M3 - Article
C2 - 11777857
AN - SCOPUS:0036148182
SN - 1071-412X
VL - 9
SP - 201
EP - 204
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
IS - 1
ER -