Biological activity of a mouse-human chimeric immunoglobulin G2 antibody to Cryptococcus neoformans polysaccharide

Katherine Westin Kwon, Nikoletta Lendvai, Sherie Morrison, K. Ryan Trinh, Arturo Casadevall

Research output: Contribution to journalArticle

Abstract

The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume9
Issue number1
DOIs
Publication statusPublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Clinical Biochemistry
  • Immunology

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