Biologic properties of a purified antigen-specific suppressive glycopeptide

M. Fresno, L. Mc-Vay Boudreau, G. Nabel, H. Cantor

Research output: Contribution to journalArticle

Abstract

Activation of antibody-forming (B) lymphocytes to most antigens requires induction by thymus-derived (T) lymphocytes. In addition, analysis of T cells has shown that this class of lymphocyte is capable of exerting specific suppressive effects. These two functions are mediated by different sets of T lymphocytes that each express a different and characteristic pattern of cell-surface glycoproteins. In addition, unlike T-helper cells, suppressor T cells can bind to antigen-coated columns. Recently supernates from cultures in vitro suppressor cells have been shown to mimic the action of T suppressor cells. However, so far, analysis of this material has not permitted a clear insight into the structural basis of antigen-specific suppression. We have developed a general method that allows the production of large numbers of continuous propagatable antigen specific inducer or suppressor clones. Analysis of these clones reveals that all Ly-1-,2+ clones tested carry suppressor but not helper activity and secrete a characteristic pattern of polypeptides that differ from other cloned T-cell sets. The ability to generate large numbers of cloned, antigen-specific suppressor T-cells has allowed us to analyze the structural basis of specific suppressive activity. We describe here the characteristics of an antigen specific suppressor molecule secreted by one of these clones.

Original languageEnglish (US)
Pages (from-to)1124-1127
Number of pages4
JournalTransplantation Proceedings
Volume13
Issue number1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Fresno, M., Mc-Vay Boudreau, L., Nabel, G., & Cantor, H. (1981). Biologic properties of a purified antigen-specific suppressive glycopeptide. Transplantation Proceedings, 13(1), 1124-1127.