Activation of antibody-forming (B) lymphocytes to most antigens requires induction by thymus-derived (T) lymphocytes. In addition, analysis of T cells has shown that this class of lymphocyte is capable of exerting specific suppressive effects. These two functions are mediated by different sets of T lymphocytes that each express a different and characteristic pattern of cell-surface glycoproteins. In addition, unlike T-helper cells, suppressor T cells can bind to antigen-coated columns. Recently supernates from cultures in vitro suppressor cells have been shown to mimic the action of T suppressor cells. However, so far, analysis of this material has not permitted a clear insight into the structural basis of antigen-specific suppression. We have developed a general method that allows the production of large numbers of continuous propagatable antigen specific inducer or suppressor clones. Analysis of these clones reveals that all Ly-1-,2+ clones tested carry suppressor but not helper activity and secrete a characteristic pattern of polypeptides that differ from other cloned T-cell sets. The ability to generate large numbers of cloned, antigen-specific suppressor T-cells has allowed us to analyze the structural basis of specific suppressive activity. We describe here the characteristics of an antigen specific suppressor molecule secreted by one of these clones.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1981|
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