TY - JOUR
T1 - Biologic markers of ovarian reserve and reproductive aging
T2 - application in a cohort study of HIV infection in women
AU - Seifer, David B.
AU - Golub, Elizabeth T.
AU - Lambert-Messerlian, Geralyn
AU - Springer, Gayle
AU - Holman, Susan
AU - Moxley, Michael
AU - Cejtin, Helen
AU - Nathwani, Niyati
AU - Anastos, Kathryn
AU - Minkoff, Howard
AU - Greenblatt, Ruth M.
N1 - Funding Information:
Data in this manuscript were collected by the Women's Interagency HIV Study (WIHS) Collaborative Study Group with centers (Principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington, DC Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The WIHS is funded by the National Institute of Allergy and Infectious Diseases with supplemental funding from the National Cancer Institute, and the National Institute on Drug Abuse (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590). Funding was also provided by the National Institute of Child Health and Human Development (grant UO1-HD-23632) and the National Center for Research Resources (grants MO1-RR-00071, MO1-RR-00079, MO1-RR-00083).
PY - 2007/12
Y1 - 2007/12
N2 - Objective: To compare Müllerian inhibiting substance (MIS) levels in serum obtained during the early follicular phase to those obtained randomly during the menstrual cycle. To determine whether HIV infection influences early follicular MIS levels, an early marker of ovarian aging. Design: A cross-sectional study. Setting: Women's Interagency HIV Study, a multicenter prospective study. Patient(s): Serum samples obtained from 263 (187 HIV infected and 76 uninfected) participants of the Women's Interagency HIV Study who reported menstrual bleeding during the preceding 6 months and who were not taking exogenous hormones. Intervention(s): Early follicular (cycle days 2-5) MIS samples were compared with serum samples that had been obtained without regard to menstrual cycle phase. Comparison samples were obtained within 6 weeks before or within 3 to 6 months after the early follicular samples. Early follicular FSH, E2, inhibin B, and MIS levels were also compared between the HIV infected and uninfected women. Main Outcome Measure(s): Correlation between early follicular MIS and prior and subsequent samples. Comparison of serum markers of ovarian reserve between HIV positive and negative women. Result(s): The MIS values from early follicular and other random cycle phases were highly correlated with each other (r > 0.93). In multivariate analysis, increased age and FSH level and lower inhibin B levels were associated with lower MIS level; MIS values did not vary by HIV serostatus. Conclusion(s): Without regard to cycle phase, MIS was similar during early follicular phase and highly correlated with early follicular FSH and inhibin B in women with and without HIV. Measurement of serum MIS offers a simplified method of determining ovarian reserve using specimens obtained without menstrual phase timing. Furthermore, using biologic measures of reproductive aging, we found no evidence that HIV infection influences ovarian aging.
AB - Objective: To compare Müllerian inhibiting substance (MIS) levels in serum obtained during the early follicular phase to those obtained randomly during the menstrual cycle. To determine whether HIV infection influences early follicular MIS levels, an early marker of ovarian aging. Design: A cross-sectional study. Setting: Women's Interagency HIV Study, a multicenter prospective study. Patient(s): Serum samples obtained from 263 (187 HIV infected and 76 uninfected) participants of the Women's Interagency HIV Study who reported menstrual bleeding during the preceding 6 months and who were not taking exogenous hormones. Intervention(s): Early follicular (cycle days 2-5) MIS samples were compared with serum samples that had been obtained without regard to menstrual cycle phase. Comparison samples were obtained within 6 weeks before or within 3 to 6 months after the early follicular samples. Early follicular FSH, E2, inhibin B, and MIS levels were also compared between the HIV infected and uninfected women. Main Outcome Measure(s): Correlation between early follicular MIS and prior and subsequent samples. Comparison of serum markers of ovarian reserve between HIV positive and negative women. Result(s): The MIS values from early follicular and other random cycle phases were highly correlated with each other (r > 0.93). In multivariate analysis, increased age and FSH level and lower inhibin B levels were associated with lower MIS level; MIS values did not vary by HIV serostatus. Conclusion(s): Without regard to cycle phase, MIS was similar during early follicular phase and highly correlated with early follicular FSH and inhibin B in women with and without HIV. Measurement of serum MIS offers a simplified method of determining ovarian reserve using specimens obtained without menstrual phase timing. Furthermore, using biologic measures of reproductive aging, we found no evidence that HIV infection influences ovarian aging.
KW - HIV
KW - Müllerian inhibiting substance
KW - ovarian reserve
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U2 - 10.1016/j.fertnstert.2007.01.122
DO - 10.1016/j.fertnstert.2007.01.122
M3 - Article
C2 - 17418155
AN - SCOPUS:36749015719
SN - 0015-0282
VL - 88
SP - 1645
EP - 1652
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -