Biologic characteristics of long-term autogenous vein grafts: A dynamic evolution

Thomas Reifsnyder, Jonathan B. Towne, Gary R. Seabrook, Jean F. Blair, Dennis F. Bandyk

Research output: Contribution to journalArticle

Abstract

Purpose: The venous conduit as an arterial substitute has dynamic biologic properties that affect its durability. This study evaluated the morphologic and physiologic characteristics of 72 lower extremity vein grafts functioning at 4.5 to 21.6 years (median 6.6 years). Methods: The entire graft was imaged with use of color duplex ultrasonography and then classified as normal (class I), abnormal but not graft-threatening (class II), or abnormal and graft-threatening (class III) for the proximal, middle, and distal thirds. Thirty-one grafts (43%) were classified as normal, whereas 41 (57%) were classified as abnormal, with 58 class II and 15 class III segments. Results: Three types of abnormalities were found by duplex imaging: nonstenotic wall plaques, discrete stenoses, and aneurysmal dilation. Aneurysms developed in five of seven grafts that had required thrombectomy in the distant past (mean of 40 months). There were 70 postoperative revisions in 38 limbs (53%). In 23 (60%) the conduit was revised, in 11 (29%) the revisions corrected progression of native artery atherosclerotic disease, and in 4 (11%) both types of revisions were required. Eleven grafts were revised in the first 30 days to correct technical errors. Eighteen limbs were revised between 1 and 24 months, with 12 (67%) of the revisions correcting stenotic lesions in the conduit or at one of the anastomoses. After 24 months 12 (67%) of 18 limbs were revised to correct progression of occlusive disease in the inflow or outflow vessels. At the time of this study 18 (67%) of the 27 conduits revised for intrinsic lesions were abnormal by color duplex imaging, and they harbored 12 (80%) of the 15-graft-threatening lesions. Conclusions: Autogenous vein remains the most durable arterial conduit, but vigilant surveillance is essential because the atherosclerotic environment continually produces lesions that may imperil the longevity of the graft.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalJournal of Vascular Surgery
Volume17
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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Veins
Transplants
Extremities
Color
Thrombectomy
Time and Motion Studies
Aneurysm
Disease Progression
Dilatation
Lower Extremity
Ultrasonography
Pathologic Constriction
Arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Biologic characteristics of long-term autogenous vein grafts : A dynamic evolution. / Reifsnyder, Thomas; Towne, Jonathan B.; Seabrook, Gary R.; Blair, Jean F.; Bandyk, Dennis F.

In: Journal of Vascular Surgery, Vol. 17, No. 1, 1993, p. 207-217.

Research output: Contribution to journalArticle

Reifsnyder, Thomas ; Towne, Jonathan B. ; Seabrook, Gary R. ; Blair, Jean F. ; Bandyk, Dennis F. / Biologic characteristics of long-term autogenous vein grafts : A dynamic evolution. In: Journal of Vascular Surgery. 1993 ; Vol. 17, No. 1. pp. 207-217.
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abstract = "Purpose: The venous conduit as an arterial substitute has dynamic biologic properties that affect its durability. This study evaluated the morphologic and physiologic characteristics of 72 lower extremity vein grafts functioning at 4.5 to 21.6 years (median 6.6 years). Methods: The entire graft was imaged with use of color duplex ultrasonography and then classified as normal (class I), abnormal but not graft-threatening (class II), or abnormal and graft-threatening (class III) for the proximal, middle, and distal thirds. Thirty-one grafts (43{\%}) were classified as normal, whereas 41 (57{\%}) were classified as abnormal, with 58 class II and 15 class III segments. Results: Three types of abnormalities were found by duplex imaging: nonstenotic wall plaques, discrete stenoses, and aneurysmal dilation. Aneurysms developed in five of seven grafts that had required thrombectomy in the distant past (mean of 40 months). There were 70 postoperative revisions in 38 limbs (53{\%}). In 23 (60{\%}) the conduit was revised, in 11 (29{\%}) the revisions corrected progression of native artery atherosclerotic disease, and in 4 (11{\%}) both types of revisions were required. Eleven grafts were revised in the first 30 days to correct technical errors. Eighteen limbs were revised between 1 and 24 months, with 12 (67{\%}) of the revisions correcting stenotic lesions in the conduit or at one of the anastomoses. After 24 months 12 (67{\%}) of 18 limbs were revised to correct progression of occlusive disease in the inflow or outflow vessels. At the time of this study 18 (67{\%}) of the 27 conduits revised for intrinsic lesions were abnormal by color duplex imaging, and they harbored 12 (80{\%}) of the 15-graft-threatening lesions. Conclusions: Autogenous vein remains the most durable arterial conduit, but vigilant surveillance is essential because the atherosclerotic environment continually produces lesions that may imperil the longevity of the graft.",
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