Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo

Siddharth Jhunjhunwala, Giorgio Raimondi, Andrew J. Glowacki, Sherri J. Hall, Dan Maskarinec, Stephen H. Thorne, Angus W. Thomson, Steven R. Little

Research output: Contribution to journalArticle

Abstract

A rationally designed controlled-release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads to local regulatory T cell recruitment as well as a delay in rejection responses against transplanted allogeneic cells.

Original languageEnglish (US)
Pages (from-to)4735-4738
Number of pages4
JournalAdvanced Materials
Volume24
Issue number35
DOIs
StatePublished - Sep 11 2012

Keywords

  • chemokine
  • controlled release
  • microparticles
  • polymeric materials
  • regulatory T cells

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Jhunjhunwala, S., Raimondi, G., Glowacki, A. J., Hall, S. J., Maskarinec, D., Thorne, S. H., Thomson, A. W., & Little, S. R. (2012). Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo. Advanced Materials, 24(35), 4735-4738. https://doi.org/10.1002/adma.201202513