Bioinformatics in neurosurgery

Michael D. Taylor, Todd G. Mainprize, James T. Rutka, Henry Brem, Joseph M. Piepmeier

Research output: Contribution to journalReview articlepeer-review


WITH THE COMPLETION of the Human Genome Project, the amount of molecular biological sequence data available in public databases has reached staggering proportions. Data continue to accumulate at an exponential rate in the postgenomic era. Compilation, storage, searching, sharing, studying, and transmitting of all these data present formidable challenges. To keep pace with this extant database, the science of bioinformatics (sometimes called computational biology) has evolved. Bioinformatics is the combination of biology and computers and usually involves the storage or analysis of molecular biological sequence data at either the deoxyribonucleic acid, ribonucleic acid, or protein (amino acid) level. Most bioinformatics tools are freely available on the Internet for use by investigators around the globe. The collective wisdom from bioinformatics databases worldwide will continue to spawn advances in the neurological sciences for generations to come. Neurosurgeons must be aware of the power and potential applications of bioinformatics for the analysis of neurosurgical diseases.

Original languageEnglish (US)
Pages (from-to)723-731
Number of pages9
Issue number4
StatePublished - Apr 1 2003
Externally publishedYes


  • Bioinformatics
  • Genes
  • Genomics
  • Internet
  • Molecular biology
  • National Center for Biotechnology Information
  • Proteomics

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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