Biogenesis of synaptic vesicles

R. B. Kelly, F. Bonzelius, A. Cleves, L. Clift-O'Grady, E. Grote, G. Herman

Research output: Contribution to journalArticlepeer-review

Abstract

The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalJournal of cell science
Volume106
Issue numberSUPPL. 17
DOIs
StatePublished - 1993

Keywords

  • Endosome
  • PC12 cells
  • Synaptic vesicles
  • Synaptobrevin
  • VAMP

ASJC Scopus subject areas

  • Cell Biology

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