Biofilms in the large bowel suggest an apparent function of the human vermiform appendix

R. Randal Bollinger, Andrew S. Barbas, Errol L. Bush, Shu S. Lin, William Parker

Research output: Contribution to journalArticlepeer-review

Abstract

The human vermiform ("worm-like") appendix is a 5-10 cm long and 0.5-1 cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. The function of the human appendix has long been a matter of debate, with the structure often considered to be a vestige of evolutionary development despite evidence to the contrary based on comparative primate anatomy. The appendix is thought to have some immune function based on its association with substantial lymphatic tissue, although the specific nature of that putative function is unknown. Based (a) on a recently acquired understanding of immune-mediated biofilm formation by commensal bacteria in the mammalian gut, (b) on biofilm distribution in the large bowel, (c) the association of lymphoid tissue with the appendix, (d) the potential for biofilms to protect and support colonization by commensal bacteria, and (e) on the architecture of the human bowel, we propose that the human appendix is well suited as a "safe house" for commensal bacteria, providing support for bacterial growth and potentially facilitating re-inoculation of the colon in the event that the contents of the intestinal tract are purged following exposure to a pathogen.

Original languageEnglish (US)
Pages (from-to)826-831
Number of pages6
JournalJournal of Theoretical Biology
Volume249
Issue number4
DOIs
StatePublished - Dec 21 2007
Externally publishedYes

Keywords

  • Bioreactor
  • Commensal
  • Immunoglobulin A
  • Mucus
  • Safe house

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Fingerprint Dive into the research topics of 'Biofilms in the large bowel suggest an apparent function of the human vermiform appendix'. Together they form a unique fingerprint.

Cite this