Biofilm formation by Cryptococcus neoformans

Luis R. Martinez, Arturo Casadevall

Research output: Contribution to journalArticle

Abstract

The fungus Cryptococcus neoformans possesses a polysaccharide capsule and can form biofilms on medical devices. The increasing use of ventriculoperitoneal shunts to manage intracranial hypertension associated with cryptococcal meningoencephalitis highlights the importance of investigating the biofilm-forming properties of this organism. Like other microbe-forming biofilms, C. neoformans biofilms are resistant to antimicrobial agents and host defense mechanisms, causing significant morbidity and mortality. This chapter discusses the recent advances in the understanding of cryptococcal biofilms, including the role of its polysaccharide capsule in adherence, gene expression, and quorum sensing in biofilm formation. We describe novel strategies for the prevention or eradication of cryptococcal colonization of medical prosthetic devices. Finally, we provide fresh thoughts on the diverse but interesting directions of research in this field that may result in new insights into C. neoformans biology.

Original languageEnglish (US)
Article numberMB-0006-2014
JournalMicrobiology spectrum
Volume3
Issue number3
DOIs
StatePublished - 2015

Fingerprint

Cryptococcus neoformans
Biofilms
biofilm
polysaccharide
Capsules
Polysaccharides
Ventriculoperitoneal Shunt
Quorum Sensing
Equipment and Supplies
hypertension
Meningoencephalitis
Intracranial Hypertension
defense mechanism
morbidity
Anti-Infective Agents
gene expression
Fungi
colonization
fungus
Morbidity

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Microbiology (medical)
  • Ecology
  • Cell Biology
  • Genetics
  • Physiology

Cite this

Biofilm formation by Cryptococcus neoformans. / Martinez, Luis R.; Casadevall, Arturo.

In: Microbiology spectrum, Vol. 3, No. 3, MB-0006-2014, 2015.

Research output: Contribution to journalArticle

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