Bioengineered human heart and skeletal muscles on chips: Methods and applications

Ki Hwan Nam; Mikael Perla; Alec S.T. Smith; Deok Ho Kim

doi:10.1007/978-3-319-21813-7_9

Bioengineered human heart and skeletal muscles on chips: Methods and applications

Ki Hwan Nam, Mikael Perla, Alec S.T. Smith, Deok Ho Kim

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.

Original language	English (US)
Title of host publication	Biomedical Engineering
Subtitle of host publication	Frontier Research and Converging Technologies
Publisher	Springer International Publishing
Pages	199-208
Number of pages	10
Volume	9
ISBN (Electronic)	9783319218137
ISBN (Print)	9783319218120
DOIs	https://doi.org/10.1007/978-3-319-21813-7_9
State	Published - Jul 23 2015
Externally published	Yes

Keywords

Heart-on-chip
Micro/nanofabrication
Muscle-on-chip
Organ-on-chip

ASJC Scopus subject areas

General Engineering
General Medicine
General Neuroscience
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-3-319-21813-7_9

Cite this

@inbook{6cf056692c12463e828e026b1fa2fe9a,

title = "Bioengineered human heart and skeletal muscles on chips: Methods and applications",

abstract = "This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.",

keywords = "Heart-on-chip, Micro/nanofabrication, Muscle-on-chip, Organ-on-chip",

author = "Nam, {Ki Hwan} and Mikael Perla and Smith, {Alec S.T.} and Kim, {Deok Ho}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016. All rights are reserved.",

year = "2015",

month = jul,

day = "23",

doi = "10.1007/978-3-319-21813-7_9",

language = "English (US)",

isbn = "9783319218120",

volume = "9",

pages = "199--208",

booktitle = "Biomedical Engineering",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Bioengineered human heart and skeletal muscles on chips

T2 - Methods and applications

AU - Nam, Ki Hwan

AU - Perla, Mikael

AU - Smith, Alec S.T.

AU - Kim, Deok Ho

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2016. All rights are reserved.

PY - 2015/7/23

Y1 - 2015/7/23

N2 - This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.

AB - This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.

KW - Heart-on-chip

KW - Micro/nanofabrication

KW - Muscle-on-chip

KW - Organ-on-chip

UR - http://www.scopus.com/inward/record.url?scp=84956839413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956839413&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-21813-7_9

DO - 10.1007/978-3-319-21813-7_9

M3 - Chapter

AN - SCOPUS:84956839413

SN - 9783319218120

VL - 9

SP - 199

EP - 208

BT - Biomedical Engineering

PB - Springer International Publishing

ER -

Bioengineered human heart and skeletal muscles on chips: Methods and applications

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this