Bioengineered human heart and skeletal muscles on chips: Methods and applications

Ki Hwan Nam, Mikael Perla, Alec S.T. Smith, Deok Ho Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter introduces innovative organ-on-chip platforms for chemical assay and toxicity testing that measures the physiological properties of live, engineered muscular tissue samples. The advantages of using such engineered tissues for drug screening compared to more conventional cell-based assays are discussed. Specifically, this chapter will outline recent developments and applications of cardiac and skeletal muscle organ-on-chip systems. Recent advances in micro- and nanofabrication techniques, along with their biological applications with regard to organ-on-chips, are also reviewed in this chapter.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering
Subtitle of host publicationFrontier Research and Converging Technologies
PublisherSpringer International Publishing
Pages199-208
Number of pages10
Volume9
ISBN (Electronic)9783319218137
ISBN (Print)9783319218120
DOIs
StatePublished - Jul 23 2015
Externally publishedYes

Keywords

  • Heart-on-chip
  • Micro/nanofabrication
  • Muscle-on-chip
  • Organ-on-chip

ASJC Scopus subject areas

  • Engineering(all)
  • Medicine(all)
  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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