TY - JOUR
T1 - Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients
AU - Van Der Veldt, Astrid A.M.
AU - Hendrikse, N. Harry
AU - Smit, Egbert F.
AU - Mooijer, Martien P.J.
AU - Rijnders, Anneloes Y.
AU - Gerritsen, Winald R.
AU - Van Der Hoeven, Jacobus J.M.
AU - Windhorst, Albert D.
AU - Lammertsma, Adriaan A.
AU - Lubberink, Mark
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Purpose Docetaxel is an important chemotherapeutic agent used for the treatment of several cancer types. As radio-labelled anticancer agents provide a potential means for personalized treatment planning, docetaxel was labelled with the positron emitter 11C. Non-invasive measurements of [ 11C]docetaxel uptake in organs and tumours may provide additional information on pharmacokinetics and pharmacodynamics of the drug docetaxel. The purpose of the present study was to determine the biodistribution and radiation absorbed dose of [ 11C]docetaxel in humans. Methods Biodistribution of [ 11C]docetaxel was measured in seven patients (five men and two women) with solid tumours using PET/CT. Venous blood samples were collected to measure activity in blood and plasma. Regions of interest (ROI) for various source organs were defined on PET (high [ 11C]docetaxel uptake) or CT (low [ 11C] docetaxel uptake). ROI data were used to generate time-activity curves and to calculate percentage injected dose and residence times. Radiation absorbed doses were calculated according to the MIRD method using OLINDA/EXM 1.0 software. Results Gall bladder and liver demonstrated high [ 11C] docetaxel uptake, whilst uptake in brain and normal lung was low. The percentage injected dose at 1 h in the liver was 47±9%. [ 11C]docetaxel was rapidly cleared from plasma and no radiolabelled metabolites were detected. [ 11C]docetaxel uptake in tumours was moderate and highly variable between tumours. Conclusion The effective dose of [ 11C]docetaxel was 4.7 μSv/MBq. As uptake in normal lung is low, [ 11C] docetaxel may be a promising tracer for tumours in the thoracic region.
AB - Purpose Docetaxel is an important chemotherapeutic agent used for the treatment of several cancer types. As radio-labelled anticancer agents provide a potential means for personalized treatment planning, docetaxel was labelled with the positron emitter 11C. Non-invasive measurements of [ 11C]docetaxel uptake in organs and tumours may provide additional information on pharmacokinetics and pharmacodynamics of the drug docetaxel. The purpose of the present study was to determine the biodistribution and radiation absorbed dose of [ 11C]docetaxel in humans. Methods Biodistribution of [ 11C]docetaxel was measured in seven patients (five men and two women) with solid tumours using PET/CT. Venous blood samples were collected to measure activity in blood and plasma. Regions of interest (ROI) for various source organs were defined on PET (high [ 11C]docetaxel uptake) or CT (low [ 11C] docetaxel uptake). ROI data were used to generate time-activity curves and to calculate percentage injected dose and residence times. Radiation absorbed doses were calculated according to the MIRD method using OLINDA/EXM 1.0 software. Results Gall bladder and liver demonstrated high [ 11C] docetaxel uptake, whilst uptake in brain and normal lung was low. The percentage injected dose at 1 h in the liver was 47±9%. [ 11C]docetaxel was rapidly cleared from plasma and no radiolabelled metabolites were detected. [ 11C]docetaxel uptake in tumours was moderate and highly variable between tumours. Conclusion The effective dose of [ 11C]docetaxel was 4.7 μSv/MBq. As uptake in normal lung is low, [ 11C] docetaxel may be a promising tracer for tumours in the thoracic region.
KW - Biodistribution
KW - Cancer. PET/CT
KW - Radiation Dose
KW - [ C]docetaxel
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U2 - 10.1007/s00259-010-1489-y
DO - 10.1007/s00259-010-1489-y
M3 - Article
C2 - 20508935
AN - SCOPUS:79952109774
SN - 1619-7070
VL - 37
SP - 1950
EP - 1958
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 10
ER -