TY - JOUR
T1 - Biodegradable stimuli-responsive polymeric micelles for treatment of malignancy
AU - Yan, Lesan
AU - Li, Xingde
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - In the past decade, drug delivery systems that can respond to the tumor microenvironment or external stimuli have emerged as promising platforms for treating malignancies due to their improved antitumor efficacy and reduced side effects. In particular, biodegradable polymeric micelles have attracted increasing attention and been rapidly developed as a distinct therapeutic to overcome limitations of conventional chemotherapeutic anticancer drugs. Because of their advantages with respect to biocompatibility, degradability, circulation time, and tumor accumulation, considerable effort has been dedicated to the developing and optimizing micellar systems during the past few years. This review highlights recent advances concerning stimuli-responsive micelles made of biodegradable polypeptide and polyester as nanocarries for drug delivery, and especially limits the content to pH sensitive, redox sensitive, and photo-sensitive micellar systems for safe and efficient cancer chemotherapy.
AB - In the past decade, drug delivery systems that can respond to the tumor microenvironment or external stimuli have emerged as promising platforms for treating malignancies due to their improved antitumor efficacy and reduced side effects. In particular, biodegradable polymeric micelles have attracted increasing attention and been rapidly developed as a distinct therapeutic to overcome limitations of conventional chemotherapeutic anticancer drugs. Because of their advantages with respect to biocompatibility, degradability, circulation time, and tumor accumulation, considerable effort has been dedicated to the developing and optimizing micellar systems during the past few years. This review highlights recent advances concerning stimuli-responsive micelles made of biodegradable polypeptide and polyester as nanocarries for drug delivery, and especially limits the content to pH sensitive, redox sensitive, and photo-sensitive micellar systems for safe and efficient cancer chemotherapy.
KW - Drug delivery
KW - Polymeric micelles
KW - Polypeptide and polyester
KW - Stimuli-responsive
UR - http://www.scopus.com/inward/record.url?scp=84958955896&partnerID=8YFLogxK
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U2 - 10.2174/138920101703160206142821
DO - 10.2174/138920101703160206142821
M3 - Article
C2 - 26873075
AN - SCOPUS:84958955896
SN - 1389-2010
VL - 17
SP - 227
EP - 236
JO - Current Pharmaceutical Biotechnology
JF - Current Pharmaceutical Biotechnology
IS - 3
ER -