Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus

Ming Yang, Samuel K. Lai, Ying Ying Wang, Weixi Zhong, Christina Happe, Michael Zhang, Jie Fu, Justin Hanes

Research output: Contribution to journalArticle

Abstract

Slipping through: Pluronic molecules adsorb onto nanoparticle surfaces through their polypropylene oxide (PPO) segments with the flanking polyethylene glycol (PEG) segments forming a dense muco-inert brush (see picture; top). While uncoated particles are immobilized in mucus through adhesive interactions with mucus mesh elements, coated particles diffuse rapidly through spaces in the mucus mesh (bottom).

Original languageEnglish (US)
Pages (from-to)2597-2600
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number11
DOIs
StatePublished - Mar 7 2011

Keywords

  • GRAS (generally recognized as safe)
  • Pluronics
  • drug delivery
  • mucus-penetrating particles
  • nanotechnology

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus'. Together they form a unique fingerprint.

  • Cite this