Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus

Ming Yang, Samuel K. Lai, Ying Ying Wang, Weixi Zhong, Christina Happe, Michael Zhang, Jie Fu, Justin S Hanes

Research output: Contribution to journalArticle

Abstract

Slipping through: Pluronic molecules adsorb onto nanoparticle surfaces through their polypropylene oxide (PPO) segments with the flanking polyethylene glycol (PEG) segments forming a dense muco-inert brush (see picture; top). While uncoated particles are immobilized in mucus through adhesive interactions with mucus mesh elements, coated particles diffuse rapidly through spaces in the mucus mesh (bottom).

Original languageEnglish (US)
Pages (from-to)2597-2600
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number11
DOIs
StatePublished - Mar 7 2011

Fingerprint

Polypropylene oxides
Poloxamer
Brushes
Polyethylene glycols
Adhesives
Nanoparticles
Molecules

Keywords

  • drug delivery
  • GRAS (generally recognized as safe)
  • mucus-penetrating particles
  • nanotechnology
  • Pluronics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. / Yang, Ming; Lai, Samuel K.; Wang, Ying Ying; Zhong, Weixi; Happe, Christina; Zhang, Michael; Fu, Jie; Hanes, Justin S.

In: Angewandte Chemie - International Edition, Vol. 50, No. 11, 07.03.2011, p. 2597-2600.

Research output: Contribution to journalArticle

Yang, Ming ; Lai, Samuel K. ; Wang, Ying Ying ; Zhong, Weixi ; Happe, Christina ; Zhang, Michael ; Fu, Jie ; Hanes, Justin S. / Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 11. pp. 2597-2600.
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