Biodegradable foams for cell transplantation

H. Lo, S. Kadiyala, S. E. Guggino, K. W. Leong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A processing technique based on the principle of phase separation was developed to fabricate three-dimensional microcellular foams to act as templates for cell transplantation. The polymers used to make the foams were polylactic acid (PLLA) and a polyphosphoester (BPA/ PP). The resulting foams had relatively uniform, open cells throughout the matrix. The foams could also be fabricated into complex shapes to meet specific design requirements. The foam morphology and microstructure were characterized by mercury porosimetry and scanning electron microscopy. Osteoblast like cells ROS17/2.8 were successfully cultured in the foams. Cell attachment to the foam interior was verified by confocal microscopy.The fabrication technique allows incorporation of drugs or nutrients into the highly porous structure as demonstrated by the intimate dispersion of fluorescein isothiocyanate (FITC) in the matrix.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
PublisherPubl by Materials Research Society
Pages41-46
Number of pages6
ISBN (Print)1558992308
StatePublished - Jan 1 1994
EventProceedings of the Biomaterials for Drug and Cell Delivery - Boston, MA, USA
Duration: Nov 29 1993Dec 1 1993

Publication series

NameMaterials Research Society Symposium Proceedings
Volume331
ISSN (Print)0272-9172

Other

OtherProceedings of the Biomaterials for Drug and Cell Delivery
CityBoston, MA, USA
Period11/29/9312/1/93

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Lo, H., Kadiyala, S., Guggino, S. E., & Leong, K. W. (1994). Biodegradable foams for cell transplantation. In Materials Research Society Symposium Proceedings (pp. 41-46). (Materials Research Society Symposium Proceedings; Vol. 331). Publ by Materials Research Society.