Biodegradable electroactive polymers for electrochemically-triggered drug delivery

John G. Hardy, David J. Mouser, Netzahualcoyotl Arroyo-Curras, Sydney Geissler, Jacqueline K. Chow, Lindsey Nguy, Jong M. Kim, Christine E. Schmidt

Research output: Contribution to journalArticle

Abstract

We report biodegradable electroactive polymer (EAP)-based materials and their application as drug delivery devices. Copolymers composed of oligoaniline-based electroactive blocks linked to either polyethylene glycol or polycaprolactone blocks via ester bonds were synthesized in three steps from commercially available starting materials and isolated without the need for column chromatography. The physicochemical and electrochemical properties of the polymers were characterized with a variety of techniques. The ability of the polymers to deliver the anti-inflammatory drug dexamethasone phosphate on the application of electrochemical stimuli was studied spectroscopically. Films of the polymers were shown to be degradable and cell adhesive in vitro. Such EAP-based materials have prospects for integration in implantable fully biodegradable/bioerodible EAP-based drug delivery devices that are capable of controlling the chronopharmacology of drugs for future clinical application.

Original languageEnglish (US)
Pages (from-to)6809-6822
Number of pages14
JournalJournal of Materials Chemistry B
Volume2
Issue number39
DOIs
StatePublished - Oct 21 2014

Fingerprint

Drug delivery
Polymers
dexamethasone 21-phosphate
Polycaprolactone
Column chromatography
Electrochemical properties
Pharmaceutical Preparations
Polyethylene glycols
Adhesives
Esters
Phosphates
Anti-Inflammatory Agents
Copolymers

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Hardy, J. G., Mouser, D. J., Arroyo-Curras, N., Geissler, S., Chow, J. K., Nguy, L., ... Schmidt, C. E. (2014). Biodegradable electroactive polymers for electrochemically-triggered drug delivery. Journal of Materials Chemistry B, 2(39), 6809-6822. https://doi.org/10.1039/c4tb00355a

Biodegradable electroactive polymers for electrochemically-triggered drug delivery. / Hardy, John G.; Mouser, David J.; Arroyo-Curras, Netzahualcoyotl; Geissler, Sydney; Chow, Jacqueline K.; Nguy, Lindsey; Kim, Jong M.; Schmidt, Christine E.

In: Journal of Materials Chemistry B, Vol. 2, No. 39, 21.10.2014, p. 6809-6822.

Research output: Contribution to journalArticle

Hardy, JG, Mouser, DJ, Arroyo-Curras, N, Geissler, S, Chow, JK, Nguy, L, Kim, JM & Schmidt, CE 2014, 'Biodegradable electroactive polymers for electrochemically-triggered drug delivery', Journal of Materials Chemistry B, vol. 2, no. 39, pp. 6809-6822. https://doi.org/10.1039/c4tb00355a
Hardy, John G. ; Mouser, David J. ; Arroyo-Curras, Netzahualcoyotl ; Geissler, Sydney ; Chow, Jacqueline K. ; Nguy, Lindsey ; Kim, Jong M. ; Schmidt, Christine E. / Biodegradable electroactive polymers for electrochemically-triggered drug delivery. In: Journal of Materials Chemistry B. 2014 ; Vol. 2, No. 39. pp. 6809-6822.
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