Biodegradable and photocrosslinkable polyphosphoester hydrogel

Qiang Li, Jun Wang, Shilpa Shahani, Danny D.N. Sun, Blanka Sharma, Jennifer H. Elisseeff, Kam W. Leong

Research output: Contribution to journalArticle

Abstract

A new biodegradable, photocrosslinkable and multifunctional macromer, poly(6-aminohexyl propylene phosphate) (PPE-HA)-ACRL, was synthesized by conjugation of acrylate groups to the side chains of PPE-HA. By controlling the synthetic conditions, different weight fractions of acrylate in the macromers were achieved as confirmed by 1H NMR. The hydrogels obtained from PPE-HA-ACRL through photocrosslinking were dominantly elastic. With increasing acrylate contents in the macromers, the hydrogels exhibited a lower swelling ratio and higher mechanical strength. The hydrogels with different crosslinking densities lost between 4.3% and 37.4% of their mass in 84 days when incubated in phosphate-buffered saline at 37°C. No significant cytotoxicity of the macromers against bone marrow-derived mesenchymal stem cells from goat (GMSC) was observed at a concentration up to 10 mg/ml. Finally, GMSCs encapsulated in the photopolymerized gel maintained their viability when cultured in osteogenic medium for three weeks. Clear mineralization in the hydrogel scaffold was revealed by Von Kossa staining. This study suggests the potential of these biodegradable and photocrosslinkable as injectable tissue engineering scaffolds.

Original languageEnglish (US)
Pages (from-to)1027-1034
Number of pages8
JournalBiomaterials
Volume27
Issue number7
DOIs
StatePublished - Mar 1 2006

Keywords

  • Hydrogel
  • Osteogenesis
  • Photopolymerization
  • Polyphosphoester
  • Tissue engineering scaffold

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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  • Cite this

    Li, Q., Wang, J., Shahani, S., Sun, D. D. N., Sharma, B., Elisseeff, J. H., & Leong, K. W. (2006). Biodegradable and photocrosslinkable polyphosphoester hydrogel. Biomaterials, 27(7), 1027-1034. https://doi.org/10.1016/j.biomaterials.2005.07.019