Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

Aihui Yan, Bannie W. Lau, Bevan S. Weissman, Indrek Külaots, Nancy Y.C. Yang, Agnes B. Kane, Robert H. Hurt

Research output: Contribution to journalArticlepeer-review

Abstract

A new and flexible approach for carbon-nanoparticle fabrication for delivery to mesothelial cells, which offers explicit control of particle composition and size across the endocytic/phagocytic size ranges, is discussed. It prevents particle-to-particle aggregation and fusion, controls the surface chemistry to aid in functionalization and dispersion and avoids the growth catalysts. Aqueous solutions of a water-soluble polyaromatic liquid crystal (LC) are nebulized ultrasonically followed by drying and carbonization in the aerosol phase at modest temperature to produce near-spherical carbon nanoparticles with 'inverted' crystal structure. The new supramolecular carbon nanoparticles have clear advantages in biological applications as they are nonfused, free of metal impurities, and size-tunable by selection of the precursor concentration. Incubation with mesothelial cells shows rapid internalization with preferential perinuclear localization.

Original languageEnglish (US)
Pages (from-to)2373-2378
Number of pages6
JournalAdvanced Materials
Volume18
Issue number18
DOIs
StatePublished - Sep 18 2006
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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