Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

Aihui Yan; Bannie W. Lau; Bevan S. Weissman; Indrek Külaots; Nancy Y.C. Yang; Agnes B. Kane; Robert H. Hurt

doi:10.1002/adma.200600838

Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

Aihui Yan, Bannie W. Lau, Bevan S. Weissman, Indrek Külaots, Nancy Y.C. Yang, Agnes B. Kane, Robert H. Hurt

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

A new and flexible approach for carbon-nanoparticle fabrication for delivery to mesothelial cells, which offers explicit control of particle composition and size across the endocytic/phagocytic size ranges, is discussed. It prevents particle-to-particle aggregation and fusion, controls the surface chemistry to aid in functionalization and dispersion and avoids the growth catalysts. Aqueous solutions of a water-soluble polyaromatic liquid crystal (LC) are nebulized ultrasonically followed by drying and carbonization in the aerosol phase at modest temperature to produce near-spherical carbon nanoparticles with 'inverted' crystal structure. The new supramolecular carbon nanoparticles have clear advantages in biological applications as they are nonfused, free of metal impurities, and size-tunable by selection of the precursor concentration. Incubation with mesothelial cells shows rapid internalization with preferential perinuclear localization.

Original language	English (US)
Pages (from-to)	2373-2378
Number of pages	6
Journal	Advanced Materials
Volume	18
Issue number	18
DOIs	https://doi.org/10.1002/adma.200600838
State	Published - Sep 18 2006
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.200600838

Cite this

@article{27d8e290075f4ee2909d44a5f4225b0f,

title = "Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery",

abstract = "A new and flexible approach for carbon-nanoparticle fabrication for delivery to mesothelial cells, which offers explicit control of particle composition and size across the endocytic/phagocytic size ranges, is discussed. It prevents particle-to-particle aggregation and fusion, controls the surface chemistry to aid in functionalization and dispersion and avoids the growth catalysts. Aqueous solutions of a water-soluble polyaromatic liquid crystal (LC) are nebulized ultrasonically followed by drying and carbonization in the aerosol phase at modest temperature to produce near-spherical carbon nanoparticles with 'inverted' crystal structure. The new supramolecular carbon nanoparticles have clear advantages in biological applications as they are nonfused, free of metal impurities, and size-tunable by selection of the precursor concentration. Incubation with mesothelial cells shows rapid internalization with preferential perinuclear localization.",

author = "Aihui Yan and Lau, {Bannie W.} and Weissman, {Bevan S.} and Indrek K{\"u}laots and Yang, {Nancy Y.C.} and Kane, {Agnes B.} and Hurt, {Robert H.}",

year = "2006",

month = sep,

day = "18",

doi = "10.1002/adma.200600838",

language = "English (US)",

volume = "18",

pages = "2373--2378",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "18",

}

TY - JOUR

T1 - Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

AU - Yan, Aihui

AU - Lau, Bannie W.

AU - Weissman, Bevan S.

AU - Külaots, Indrek

AU - Yang, Nancy Y.C.

AU - Kane, Agnes B.

AU - Hurt, Robert H.

PY - 2006/9/18

Y1 - 2006/9/18

N2 - A new and flexible approach for carbon-nanoparticle fabrication for delivery to mesothelial cells, which offers explicit control of particle composition and size across the endocytic/phagocytic size ranges, is discussed. It prevents particle-to-particle aggregation and fusion, controls the surface chemistry to aid in functionalization and dispersion and avoids the growth catalysts. Aqueous solutions of a water-soluble polyaromatic liquid crystal (LC) are nebulized ultrasonically followed by drying and carbonization in the aerosol phase at modest temperature to produce near-spherical carbon nanoparticles with 'inverted' crystal structure. The new supramolecular carbon nanoparticles have clear advantages in biological applications as they are nonfused, free of metal impurities, and size-tunable by selection of the precursor concentration. Incubation with mesothelial cells shows rapid internalization with preferential perinuclear localization.

AB - A new and flexible approach for carbon-nanoparticle fabrication for delivery to mesothelial cells, which offers explicit control of particle composition and size across the endocytic/phagocytic size ranges, is discussed. It prevents particle-to-particle aggregation and fusion, controls the surface chemistry to aid in functionalization and dispersion and avoids the growth catalysts. Aqueous solutions of a water-soluble polyaromatic liquid crystal (LC) are nebulized ultrasonically followed by drying and carbonization in the aerosol phase at modest temperature to produce near-spherical carbon nanoparticles with 'inverted' crystal structure. The new supramolecular carbon nanoparticles have clear advantages in biological applications as they are nonfused, free of metal impurities, and size-tunable by selection of the precursor concentration. Incubation with mesothelial cells shows rapid internalization with preferential perinuclear localization.

UR - http://www.scopus.com/inward/record.url?scp=33749352001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749352001&partnerID=8YFLogxK

U2 - 10.1002/adma.200600838

DO - 10.1002/adma.200600838

M3 - Article

AN - SCOPUS:33749352001

SN - 0935-9648

VL - 18

SP - 2373

EP - 2378

JO - Advanced Materials

JF - Advanced Materials

IS - 18

ER -

Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this