TY - JOUR
T1 - Biocompatibility of polymeric delivery systems for macromolecules
AU - Langer, Robert
AU - Brem, Henry
AU - Tapper, David
PY - 1981/3
Y1 - 1981/3
N2 - We previously reported the use of polymeric delivery systems capable of sustained release of substances with molecular weights up to 2 × 106. The current study examined the tissue compatibilities of these slow‐release agents and of other polymeric materials. To observe in vivo host responses to specific implants, tests were conducted in the rabbit cornea. The cornea as an implant site has several advantages compared to other organs including its clarity, avascularity, sensitivity, and convenient access to view. Corneas were examined using stereomicroscopy and histology. Two polymers suitable for sustained macromolecular release, poly(hydroxyethyl methacrylate), and alcohol‐washed ethylene‐vinyl acetate copolymer, were noninflammatory. Other polymers considered for sustained macromolecular release, such as polyacrylamide and poly(vinyl pyrrolidone), produced significant inflammation.
AB - We previously reported the use of polymeric delivery systems capable of sustained release of substances with molecular weights up to 2 × 106. The current study examined the tissue compatibilities of these slow‐release agents and of other polymeric materials. To observe in vivo host responses to specific implants, tests were conducted in the rabbit cornea. The cornea as an implant site has several advantages compared to other organs including its clarity, avascularity, sensitivity, and convenient access to view. Corneas were examined using stereomicroscopy and histology. Two polymers suitable for sustained macromolecular release, poly(hydroxyethyl methacrylate), and alcohol‐washed ethylene‐vinyl acetate copolymer, were noninflammatory. Other polymers considered for sustained macromolecular release, such as polyacrylamide and poly(vinyl pyrrolidone), produced significant inflammation.
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U2 - 10.1002/jbm.820150212
DO - 10.1002/jbm.820150212
M3 - Article
C2 - 7348718
AN - SCOPUS:0019545548
SN - 0021-9304
VL - 15
SP - 267
EP - 277
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 2
ER -