Biocompatibility of polymeric delivery systems for macromolecules

Robert Langer, Henry Brem, David Tapper

Research output: Contribution to journalArticlepeer-review

Abstract

We previously reported the use of polymeric delivery systems capable of sustained release of substances with molecular weights up to 2 × 106. The current study examined the tissue compatibilities of these slow‐release agents and of other polymeric materials. To observe in vivo host responses to specific implants, tests were conducted in the rabbit cornea. The cornea as an implant site has several advantages compared to other organs including its clarity, avascularity, sensitivity, and convenient access to view. Corneas were examined using stereomicroscopy and histology. Two polymers suitable for sustained macromolecular release, poly(hydroxyethyl methacrylate), and alcohol‐washed ethylene‐vinyl acetate copolymer, were noninflammatory. Other polymers considered for sustained macromolecular release, such as polyacrylamide and poly(vinyl pyrrolidone), produced significant inflammation.

Original languageEnglish (US)
Pages (from-to)267-277
Number of pages11
JournalJournal of Biomedical Materials Research
Volume15
Issue number2
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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