Abstract
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix ™ that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix ™ was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix ™ is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix ™ has already been shown to be an excellent protective coating for new ICP monitoring chip.
Original language | English (US) |
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Pages (from-to) | 83-89 |
Number of pages | 7 |
Journal | Journal of the Mechanical Behavior of Biomedical Materials |
Volume | 45 |
DOIs | |
State | Published - May 1 2015 |
Externally published | Yes |
Keywords
- Biocompatibility
- Brain implants
- Cerebral cortex
- Reactivity
- Thermoplastic rubber
- Toxicity
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Mechanics of Materials