Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating

Jun Yang, Andrea C. Charif, Judit E. Puskas, Hannah Phillips, Kaitlyn J. Shanahan, Jessica Garsed, Aaron Fleischman, Ken Goldman, Matthew T. Luebbers, Stephen M. Dombrowski, Mark G. Luciano

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix has already been shown to be an excellent protective coating for new ICP monitoring chip.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume45
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Biocompatibility
  • Brain implants
  • Cerebral cortex
  • Reactivity
  • Thermoplastic rubber
  • Toxicity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

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