Biochemistry of Hematopoiesis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transcription factors are key mediators of hematopoiesis. During development, SCL and GATA-2 direct formation of the hemangioblast, and RUNX1 subsequently specifies adult hematopoietic stem cells (HSCs). HSCs are maintained by TEL, MLL, and c-Myb and also give rise to the megakaryocyte-erythroid progenitor under direction of GATA-1 or to the lymphoid-myeloid progenitor (LMP) under direction of PU.1. GATA-1 together with EKLF, SCL, and NF-E2 further specify the erythroid lineage, whereas RUNX1 along with the Ets factors Fli-1 and ERG direct megakaryopoiesis. Lymphoid specification is initiated from the LMP by Ikaros. Subsequent B-cell development is mediated by EBF, E2A, Pax-5, and PU.1; with T-cell development occurring under direction of GATA-3 and Notch-1. RUNX1 contributes to CTL and Treg formation. C/EBPα initiates myelopoiesis from the LMP. C/EBPα increases PU.1 expression, zippers with AP-1 proteins, and cooperates with Egr-1 and ERK signals induced by M-CSF or other cytokines to direct monopoiesis. Alternatively, C/EBPα cooperates with Gfi-1, RARα, C/EBPα, STAT3, NF-κB p50, and increased SHP2 activity induced by G-CSF to mediate granulopoiesis. Coexpression of C/EBPκ and GATA-2 in GMP specifies the eosinophils, basophils, and mast cell lineages dependent on their order of expression. Monocytes generate macrophages, osteoclasts, or myeloid dendritic cells.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages187-189
Number of pages3
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Fingerprint

Biochemistry
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
Megakaryocyte-Erythroid Progenitor Cells
Hemangioblasts
Myelopoiesis
Adult Stem Cells
Macrophage Colony-Stimulating Factor
T-cells
Basophils
Macrophages
Fasteners
Transcription Factor AP-1
Cell Lineage
Granulocyte Colony-Stimulating Factor
Osteoclasts
Myeloid Cells
Eosinophils
Mast Cells

Keywords

  • C/EBP
  • Erythroid
  • GATA-1
  • Hematopoiesis
  • Lymphoid
  • Myeloid
  • PU.1
  • RUNX1
  • Stem cell
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Friedman, A. D. (2013). Biochemistry of Hematopoiesis. In Encyclopedia of Biological Chemistry: Second Edition (pp. 187-189). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00088-8

Biochemistry of Hematopoiesis. / Friedman, Alan David.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 187-189.

Research output: Chapter in Book/Report/Conference proceedingChapter

Friedman, AD 2013, Biochemistry of Hematopoiesis. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 187-189. https://doi.org/10.1016/B978-0-12-378630-2.00088-8
Friedman AD. Biochemistry of Hematopoiesis. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 187-189 https://doi.org/10.1016/B978-0-12-378630-2.00088-8
Friedman, Alan David. / Biochemistry of Hematopoiesis. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 187-189
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