Biochemistry of Hematopoiesis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transcription factors are key mediators of hematopoiesis. During development, SCL and GATA-2 direct formation of the hemangioblast, and RUNX1 subsequently specifies adult hematopoietic stem cells (HSCs). HSCs are maintained by TEL, MLL, and c-Myb and also give rise to the megakaryocyte-erythroid progenitor under direction of GATA-1 or to the lymphoid-myeloid progenitor (LMP) under direction of PU.1. GATA-1 together with EKLF, SCL, and NF-E2 further specify the erythroid lineage, whereas RUNX1 along with the Ets factors Fli-1 and ERG direct megakaryopoiesis. Lymphoid specification is initiated from the LMP by Ikaros. Subsequent B-cell development is mediated by EBF, E2A, Pax-5, and PU.1; with T-cell development occurring under direction of GATA-3 and Notch-1. RUNX1 contributes to CTL and Treg formation. C/EBPα initiates myelopoiesis from the LMP. C/EBPα increases PU.1 expression, zippers with AP-1 proteins, and cooperates with Egr-1 and ERK signals induced by M-CSF or other cytokines to direct monopoiesis. Alternatively, C/EBPα cooperates with Gfi-1, RARα, C/EBPα, STAT3, NF-κB p50, and increased SHP2 activity induced by G-CSF to mediate granulopoiesis. Coexpression of C/EBPκ and GATA-2 in GMP specifies the eosinophils, basophils, and mast cell lineages dependent on their order of expression. Monocytes generate macrophages, osteoclasts, or myeloid dendritic cells.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages187-189
Number of pages3
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • C/EBP
  • Erythroid
  • GATA-1
  • Hematopoiesis
  • Lymphoid
  • Myeloid
  • PU.1
  • RUNX1
  • Stem cell
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Friedman, A. D. (2013). Biochemistry of Hematopoiesis. In Encyclopedia of Biological Chemistry: Second Edition (pp. 187-189). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00088-8