Biochemical relapse after primary treatment for prostate cancer: Studies on natural history and therapeutic considerations

Research output: Contribution to journalArticle

Abstract

After local treatment, a substantial proportion of patients with prostate cancer present with rising prostate specific antigen (PSA) serum levels as the only indication of disease activity. Evolving data derived from large databases that were predominantly retrospectively evaluated show that the natural history of these patients is quite variable. Various clinical and pathologic parameters have been shown to predict for the probability of development of distant metastasis, including the surgical Gleason score, time of PSA relapse after primary treatment, and PSA doubling time (PSADT). The PSADT appears to be the most important predictor of development of distant metastasis and prostate cancer-specific mortality. At present, no data support a standard management approach for these patients, and clinical trials pose a major challenge in view of the methodologic complexities involved. Patients and treating physicians should make major efforts to participate in clinical trials in this patient population.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume2
Issue number3
DOIs
StatePublished - May 1 2004

Keywords

  • Biochemical relapse
  • PSA doubling time (PSADT)
  • Prostate cancer
  • Prostate-specific antigen (PSA)
  • Salvage therapy
  • Systemic treatment

ASJC Scopus subject areas

  • Oncology

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