Bridging IgE receptors of rat mast cells and basophilic leukemia cells initiates a series of biochemical events to lead histamine release: increased phospholipid methylation is followed by Ca2+ influx and activation of phospholipase(s). This cascade mechanism of phospholipid metabolism is supported by the experiments with specific inhibitors of each step and variants of rat basophilic leukemia cells.
|Original language||English (US)|
|Number of pages||3|
|Journal||Advances in the Biosciences|
|State||Published - Dec 1 1982|
- Ca channel
- Phospholipid methylation
- arachidonic acid