Biochemical mechanism of histamine release from rat mast cells and basophilic leukemia cells

F. Hirata, F. T. Crews, J. Axelrod, A. McGivney, R. L. Siraganian, T. Ishizaka, K. Ishizaka

Research output: Contribution to journalArticle

Abstract

Bridging IgE receptors of rat mast cells and basophilic leukemia cells initiates a series of biochemical events to lead histamine release: increased phospholipid methylation is followed by Ca2+ influx and activation of phospholipase(s). This cascade mechanism of phospholipid metabolism is supported by the experiments with specific inhibitors of each step and variants of rat basophilic leukemia cells.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalAdvances in the Biosciences
Volume33
Issue numberC
StatePublished - Dec 1 1982

Keywords

  • Ca channel
  • Phospholipid methylation
  • arachidonic acid
  • mutants
  • phospholipases

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    Hirata, F., Crews, F. T., Axelrod, J., McGivney, A., Siraganian, R. L., Ishizaka, T., & Ishizaka, K. (1982). Biochemical mechanism of histamine release from rat mast cells and basophilic leukemia cells. Advances in the Biosciences, 33(C), 43-45.