Biochemical differences between serotypes of cryptococcus neoformans

J. E. Bennett, K. J. Kwon-Chung, T. S. Theodore

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Prior studies have shown that C. neoformans isolates belonging to serotypes B and C differed from serotype A and D isolates in respect to the morphology of the perfect state, geographic distribution within the U.S.A. and frequency of isolation from avian droppings. The current study found that uptake of radiolabeled l-malic acid was approximately tenfold greater in serotype B and C than in A and D isolates. Assimilation of l-malic, fumaric and succinic acids also distinguished serotypes B and C from A and D. Greening of Guizotia seed agar occurred with 18 of 32 serotype B and C but in none of 91 serotype A or D isolates. The one property not following the same line of division was relatively slow creatinine assimilation, which distinguished type A alone.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalMedical mycology
Issue number3
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases


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