Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy

Gabriel Sica, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

4-1BB (CD137) is a member of the tumor necrosis factor receptor (TNFR) superfamily that is expressed primarily on activated T cells. Crosslinking of the 4-1BB receptor activates an intracellular signal cascade that leads to the activation of NF-κB and costimulation of T cell growth. Recent evidence indicates that 4-1BB may preferentially costimulate CD8+ T cell growth and induce cytolytic activity. The cytolytic activity induced by 4-1BB crosslinking is able to eradicate large, well-established, poorly immunogenic tumors and augments allogenic T cell responses in vivo. The 4-1BB/4-1BB ligand costimulatory pathway can provide an alternative T cell costimulatory pathway in the absence of CD28, but may physiologically function as a synergistic or complementary pathway to the CD28 costimulatory pathway. Only some of the basic immunological functions of 4-1BB/4-1BB ligand have been elucidated and much study is required to determine its exact role in T cell activation.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume47
Issue number5
StatePublished - 1999
Externally publishedYes

Keywords

  • Costimulation
  • T cell activation
  • Tumor
  • Tumor necrosis factor receptor

ASJC Scopus subject areas

  • Immunology

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