Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy

Gabriel Sica, Lieping Chen

Research output: Contribution to journalArticle

Abstract

4-1BB (CD137) is a member of the tumor necrosis factor receptor (TNFR) superfamily that is expressed primarily on activated T cells. Crosslinking of the 4-1BB receptor activates an intracellular signal cascade that leads to the activation of NF-κB and costimulation of T cell growth. Recent evidence indicates that 4-1BB may preferentially costimulate CD8+ T cell growth and induce cytolytic activity. The cytolytic activity induced by 4-1BB crosslinking is able to eradicate large, well-established, poorly immunogenic tumors and augments allogenic T cell responses in vivo. The 4-1BB/4-1BB ligand costimulatory pathway can provide an alternative T cell costimulatory pathway in the absence of CD28, but may physiologically function as a synergistic or complementary pathway to the CD28 costimulatory pathway. Only some of the basic immunological functions of 4-1BB/4-1BB ligand have been elucidated and much study is required to determine its exact role in T cell activation.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume47
Issue number5
StatePublished - 1999
Externally publishedYes

Fingerprint

CD137 Antigens
4-1BB Ligand
T-Lymphocytes
Neoplasms
Therapeutics
Tumor Necrosis Factor Receptors
Growth

Keywords

  • Costimulation
  • T cell activation
  • Tumor
  • Tumor necrosis factor receptor

ASJC Scopus subject areas

  • Immunology

Cite this

Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. / Sica, Gabriel; Chen, Lieping.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 47, No. 5, 1999, p. 275-279.

Research output: Contribution to journalArticle

@article{4f5c668eb2fa4844bff7cd63a6b2cd89,
title = "Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy",
abstract = "4-1BB (CD137) is a member of the tumor necrosis factor receptor (TNFR) superfamily that is expressed primarily on activated T cells. Crosslinking of the 4-1BB receptor activates an intracellular signal cascade that leads to the activation of NF-κB and costimulation of T cell growth. Recent evidence indicates that 4-1BB may preferentially costimulate CD8+ T cell growth and induce cytolytic activity. The cytolytic activity induced by 4-1BB crosslinking is able to eradicate large, well-established, poorly immunogenic tumors and augments allogenic T cell responses in vivo. The 4-1BB/4-1BB ligand costimulatory pathway can provide an alternative T cell costimulatory pathway in the absence of CD28, but may physiologically function as a synergistic or complementary pathway to the CD28 costimulatory pathway. Only some of the basic immunological functions of 4-1BB/4-1BB ligand have been elucidated and much study is required to determine its exact role in T cell activation.",
keywords = "Costimulation, T cell activation, Tumor, Tumor necrosis factor receptor",
author = "Gabriel Sica and Lieping Chen",
year = "1999",
language = "English (US)",
volume = "47",
pages = "275--279",
journal = "Archivum Immunologiae et Therapiae Experimentalis",
issn = "0004-069X",
publisher = "Birkhauser Verlag Basel",
number = "5",

}

TY - JOUR

T1 - Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy

AU - Sica, Gabriel

AU - Chen, Lieping

PY - 1999

Y1 - 1999

N2 - 4-1BB (CD137) is a member of the tumor necrosis factor receptor (TNFR) superfamily that is expressed primarily on activated T cells. Crosslinking of the 4-1BB receptor activates an intracellular signal cascade that leads to the activation of NF-κB and costimulation of T cell growth. Recent evidence indicates that 4-1BB may preferentially costimulate CD8+ T cell growth and induce cytolytic activity. The cytolytic activity induced by 4-1BB crosslinking is able to eradicate large, well-established, poorly immunogenic tumors and augments allogenic T cell responses in vivo. The 4-1BB/4-1BB ligand costimulatory pathway can provide an alternative T cell costimulatory pathway in the absence of CD28, but may physiologically function as a synergistic or complementary pathway to the CD28 costimulatory pathway. Only some of the basic immunological functions of 4-1BB/4-1BB ligand have been elucidated and much study is required to determine its exact role in T cell activation.

AB - 4-1BB (CD137) is a member of the tumor necrosis factor receptor (TNFR) superfamily that is expressed primarily on activated T cells. Crosslinking of the 4-1BB receptor activates an intracellular signal cascade that leads to the activation of NF-κB and costimulation of T cell growth. Recent evidence indicates that 4-1BB may preferentially costimulate CD8+ T cell growth and induce cytolytic activity. The cytolytic activity induced by 4-1BB crosslinking is able to eradicate large, well-established, poorly immunogenic tumors and augments allogenic T cell responses in vivo. The 4-1BB/4-1BB ligand costimulatory pathway can provide an alternative T cell costimulatory pathway in the absence of CD28, but may physiologically function as a synergistic or complementary pathway to the CD28 costimulatory pathway. Only some of the basic immunological functions of 4-1BB/4-1BB ligand have been elucidated and much study is required to determine its exact role in T cell activation.

KW - Costimulation

KW - T cell activation

KW - Tumor

KW - Tumor necrosis factor receptor

UR - http://www.scopus.com/inward/record.url?scp=0033253965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033253965&partnerID=8YFLogxK

M3 - Article

C2 - 10604232

AN - SCOPUS:0033253965

VL - 47

SP - 275

EP - 279

JO - Archivum Immunologiae et Therapiae Experimentalis

JF - Archivum Immunologiae et Therapiae Experimentalis

SN - 0004-069X

IS - 5

ER -