Biobanking for personalized medicine

Angen Liu, Kai Pollard

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A biobank is an entity that collects, processes, stores, and distributes biospecimens and relevant data for use in basic, translational, and clinical research. Biobanking of high-quality human biospecimens such as tissue, blood and other bodily fluids along with associated patient clinical information provides a fundamental scientific infrastructure for personalized medicine. Identification of biomarkers that are specifically associated with particular medical conditions such as cancer, cardiovascular disease and neurological disorders are useful for early detection, prevention, and treatment of the diseases. The ability to determine individual tumor biomarkers and to use those biomarkers for disease diagnosis, prognosis and prediction of response to therapy is having a very significant impact on personalized medicine and is rapidly changing the way clinical care is conducted. As a critical requirement for personalized medicine is the availability of a large collection of patient samples with well annotated patient clinical and pathological data, biobanks thus play an important role in personalized medicine advancement. The goal of this chapter is to explore the role of biobanks in personalized medicine and discuss specific needs regarding biobank development for translational and clinical research, especially for personalized medicine advancement.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages55-68
Number of pages14
DOIs
StatePublished - Jan 1 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume864
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Biobank
  • Biospecimen
  • Cancer
  • Pathology
  • Personalized medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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