Binydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia

L. Elliot Hong, Ikwunga Wonodi, Matthew T. Avila, Robert W. Buchanan, Robert P. McMahon, Braxton D. Mitchell, O. Colin Stine, William T. Carpenter, Gunvant K. Thaker

Research output: Contribution to journalArticlepeer-review

Abstract

A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia.

Original languageEnglish (US)
Pages (from-to)8-11
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume136 B
Issue number1
DOIs
StatePublished - Jul 5 2005
Externally publishedYes

Keywords

  • Caucasian
  • CRMP
  • DPYSL
  • Negative symptom
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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