Abstract
We have compared the influence of a series of benzodioxane α-adrenergic antagonists in 3H-WB-4101 and 3H-clonidine binding to α-receptor sites in the brain and peripheral tissues with their pharmacological properties. The drug specificity of 3H-WB-4101 bidning is quite similar in central and peripheral tissues. Pharmacological potencies of benzodioxanes at postsynaptic α-receptors in the rat vas deferens correlate with potencies at 3H-WB-4101 but not at 3H-clonidine binding sites. These findings suggest pharmacological effects of these drugs are mediated by "α-1 postsynaptic receptors" labeled by 3H-WB-4101. For several benzodioxanes absolute pharmacological potencies at postsynaptic α-receptors of the rat vas deferens are substantially less than theie pontencies at 3H-WB-4101 sites. The potencies of benzodioxane analogues at 3H-clonidine binding sites are similar to their pharmacological potencies at presynaptic autoreceptors in the rat vas deferens.
Original language | English (US) |
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Pages (from-to) | 317-328 |
Number of pages | 12 |
Journal | European Journal of Pharmacology |
Volume | 57 |
Issue number | 4 |
DOIs | |
State | Published - Aug 15 1979 |
Keywords
- Benzodioxane
- Clonidine
- Norepinephrine
- Vas deferens
- WB-4101
- α-Receptors
ASJC Scopus subject areas
- Pharmacology