Binding of antiparkinsonian ergot derivatives to the dopamine receptor

R. L. Weir, R. E. Hruska, E. K. Silbergeld

Research output: Contribution to journalArticle

Abstract

The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine continued to inhibit binding 24 h after a single injection and also after 4 days of drug administration. Lisuride did not affect net specific binding at these periods. Apomorphine produced a mild reduction in binding after 30 min but none after 4 days. It appears that the ergot alkaloids inhibit binding of 3H-spiroperidol by binding strongly to the dopamine receptor.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalPsychopharmacology
Volume75
Issue number2
DOIs
StatePublished - Nov 1 1981

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Keywords

  • Apomorphine
  • Bromocriptine
  • Dopamine receptor
  • H-spiroperidol
  • Lisuride

ASJC Scopus subject areas

  • Pharmacology

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