Abstract
The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine continued to inhibit binding 24 h after a single injection and also after 4 days of drug administration. Lisuride did not affect net specific binding at these periods. Apomorphine produced a mild reduction in binding after 30 min but none after 4 days. It appears that the ergot alkaloids inhibit binding of 3H-spiroperidol by binding strongly to the dopamine receptor.
Original language | English (US) |
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Pages (from-to) | 119-123 |
Number of pages | 5 |
Journal | Psychopharmacology |
Volume | 75 |
Issue number | 2 |
DOIs | |
State | Published - Nov 1981 |
Externally published | Yes |
Keywords
- Apomorphine
- Bromocriptine
- Dopamine receptor
- H-spiroperidol
- Lisuride
ASJC Scopus subject areas
- Pharmacology