@article{1f8309929a094c1fb7d25b1c4d030364,
title = "Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch",
abstract = "Two related retinal cell types called ON and OFF starburst amacrines migrate to distinct laminae and signal increased (ON) or decreased (OFF) illumination. Fezf1 acts as a fate switch between the two types by activating ON and repressing OFF genes.",
keywords = "Fezf1, ON-OFF, Rnd3, amacrine, cell fate, migration, polarization, retina, starburst, transcription factor",
author = "Peng, {Yi Rong} and James, {Rebecca E.} and Wenjun Yan and Kay, {Jeremy N.} and Kolodkin, {Alex L.} and Sanes, {Joshua R.}",
note = "Funding Information: This work was supported by NIH grant R37NS029169-29 (J.R.S.), funding from the Howard Hughes Medical Institute (A.L.K.), and NIH Visual Science Training Program (VSTP) grants 5T32EY007143-20 and F32EY025114 (R.E.J.). We are grateful to Dr. Bin Chen (University of California, Santa Cruz) for generously providing Fezf1 GFP mutant mice. We thank Drs. Loyal A. Goff and Karthik Shekhar for advice on scRNA-seq analysis strategies. We thank Mallory Laboulaye at Harvard and Nicole Kropowski, Randal Hand, Natalie Hamilton, and Tim Al-Khindi at Johns Hopkins for technical assistance. We also thank members of the J.R.S. and A.L.K. laboratories for helpful discussions and comments on the manuscript. Funding Information: This work was supported by NIH grant R37NS029169-29 (J.R.S.), funding from the Howard Hughes Medical Institute (A.L.K.), and NIH Visual Science Training Program (VSTP) grants 5T32EY007143-20 and F32EY025114 (R.E.J.). We are grateful to Dr. Bin Chen (University of California, Santa Cruz) for generously providing Fezf1GFP mutant mice. We thank Drs. Loyal A. Goff and Karthik Shekhar for advice on scRNA-seq analysis strategies. We thank Mallory Laboulaye at Harvard and Nicole Kropowski, Randal Hand, Natalie Hamilton, and Tim Al-Khindi at Johns Hopkins for technical assistance. We also thank members of the J.R.S. and A.L.K. laboratories for helpful discussions and comments on the manuscript. R.E.J. A.L.K. Y.-R.P. and J.R.S. conceived and designed experiments, analyzed data, and wrote the paper. R.E.J. and Y.-R.P. performed experiments. J.N.K. generated the Megf10-Cre allele. W.Y. analyzed data. The authors declare no competing interests Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = feb,
day = "5",
doi = "10.1016/j.neuron.2019.11.002",
language = "English (US)",
volume = "105",
pages = "464--474.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}