Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch

Yi Rong Peng; Rebecca E. James; Wenjun Yan; Jeremy N. Kay; Alex L. Kolodkin; Joshua R. Sanes

doi:10.1016/j.neuron.2019.11.002

Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch

Yi Rong Peng, Rebecca E. James, Wenjun Yan, Jeremy N. Kay, Alex L. Kolodkin, Joshua R. Sanes

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two related retinal cell types called ON and OFF starburst amacrines migrate to distinct laminae and signal increased (ON) or decreased (OFF) illumination. Fezf1 acts as a fate switch between the two types by activating ON and repressing OFF genes.

Original language	English (US)
Pages (from-to)	464-474.e6
Journal	Neuron
Volume	105
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2019.11.002
State	Published - Feb 5 2020

Keywords

Fezf1
ON-OFF
Rnd3
amacrine
cell fate
migration
polarization
retina
starburst
transcription factor

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2019.11.002

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abstract = "Two related retinal cell types called ON and OFF starburst amacrines migrate to distinct laminae and signal increased (ON) or decreased (OFF) illumination. Fezf1 acts as a fate switch between the two types by activating ON and repressing OFF genes.",

keywords = "Fezf1, ON-OFF, Rnd3, amacrine, cell fate, migration, polarization, retina, starburst, transcription factor",

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AU - Kay, Jeremy N.

AU - Kolodkin, Alex L.

AU - Sanes, Joshua R.

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