Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch

Yi Rong Peng, Rebecca E. James, Wenjun Yan, Jeremy N. Kay, Alex L. Kolodkin, Joshua R. Sanes

Research output: Contribution to journalArticlepeer-review

Abstract

Two related retinal cell types called ON and OFF starburst amacrines migrate to distinct laminae and signal increased (ON) or decreased (OFF) illumination. Fezf1 acts as a fate switch between the two types by activating ON and repressing OFF genes.

Original languageEnglish (US)
Pages (from-to)464-474.e6
JournalNeuron
Volume105
Issue number3
DOIs
StatePublished - Feb 5 2020

Keywords

  • Fezf1
  • ON-OFF
  • Rnd3
  • amacrine
  • cell fate
  • migration
  • polarization
  • retina
  • starburst
  • transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

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