Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells

Allison Suarez, Tasuku Ueno, Robert Huebner, J. Michael McCaffery, Takanari Inoue

Research output: Contribution to journalArticle

Abstract

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

Original languageEnglish (US)
Article number4693
JournalScientific reports
Volume4
DOIs
StatePublished - May 6 2014

ASJC Scopus subject areas

  • General

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