Bimatoprost a review

A. Jayaprakash Patil, Thasarat S. Vajaranant, Deepak P. Edward

Research output: Contribution to journalArticlepeer-review

Abstract

Bimatoprost is a synthetic prostamide analog that is efficacious in the treatment of open-angle glaucoma, ocular hypertension and other forms of glaucoma. It reduces intraocular pressure (IOP) by increasing uveoscleral and trabecular outflow. When used as a 0.03% topical preparation once daily, it demonstrates sustained lowering of IOP of 7-8 mmHg over a 24-h period. The drug has been found to be more effective than timolol. In some studies it has shown greater ability to lower IOP when compared with other prostaglandin analogs; whereas in others all three clinically used prostaglandin analogs were found to be equally effective. It shows good IOP reduction when used in combination with other glaucoma medications. A common side effect includes mild conjunctival hyperemia, which is generally reversible. Other side effects include periorbital pigmentation, discomfort, ocular surface hyperemia and skin changes. Pharmacoeconomic data indicate that bimatoprost is cost effective in the treatment of open-angle glaucoma.

Original languageEnglish (US)
Pages (from-to)2759-2768
Number of pages10
JournalExpert Opinion on Pharmacotherapy
Volume10
Issue number16
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Bimatoprost
  • Glaucoma
  • Intraocular pressure
  • Ocular hypertension
  • Prostaglandin
  • Prostamide

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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