TY - JOUR
T1 - Bilingualism in Parkinson’s disease
T2 - Relationship to cognition and quality of life
AU - Ondri Investigators
AU - Fishman, Keera N.
AU - Roberts, Angela C.
AU - Orange, J. B.
AU - Sunderland, Kelly M.
AU - Marras, Connie
AU - Tan, Brian
AU - Steeves, Thomas
AU - Kwan, Donna
AU - Lang, Anthony E.
AU - Grimes, David
AU - Levine, Brian
AU - Masellis, Mario
AU - Binns, Malcolm A.
AU - Jog, Mandar
AU - Strother, Stephen C.
AU - McLaughlin, Paula M.
AU - Troyer, Angela K.
AU - Bartha, Robert
AU - Black, Sandra E.
AU - Borrie, Michael
AU - Corbett, Dale
AU - Finger, Elizabeth
AU - Freedman, Morris
AU - Greenberg, Barry
AU - Hegele, Robert A.
AU - Hudson, Chris
AU - McIlroy, William E.
AU - Montero-Odasso, Manuel
AU - Munoz, David G.
AU - Munoz, Douglas P.
AU - Strong, Michael J.
AU - Swartz, Richard H.
AU - Symons, Sean
AU - Tartaglia, Maria Carmela
AU - Zinman, Lorne
N1 - Funding Information:
This work was supported by the Centre for Addiction and Mental Health Foundation; Faculty of Health Sciences, Queen’s University; McMaster University; Ontario Brain Institute; Ottawa Brain and Mind Research Institute; London Health Sciences Foundation; Bruyère Research Institute; University of Ottawa Faculty of Medicine; Thunder Bay Regional Health Sciences Centre; Temerty Family Foundation; Baycrest Foundation; Windsor/Essex County ALS Association. The authors wish to thank Dr. Ellen Bialystok for valuable discussions and consultation. This research was conducted with the support of the Ontario Brain Institute, an independent non-profit corporation, funded partially by the Ontario government. The opinions, results, and conclusions are those of the authors and no endorsement by the Ontario Brain Institute is intended or should be inferred. Matching funds were provided by participant hospital and research institute foundations, including the Baycrest Foundation, Bruyère Research Institute, Centre for Addiction and Mental Health Foundation, London Health Sciences Foundation, McMaster University Faculty of Health Sciences, Ottawa Brain and Mind Research Institute, Queen’s University Faculty of Health Sciences, the Thunder Bay Regional Health Sciences Centre, the University of Ottawa Faculty of Medicine, and the Windsor/Essex County ALS Association. The Temerty Family Foundation provided the major infrastructure matching funds. This work was completed on behalf of the Ontario Neurodegenerative Disease Research Initiative (ONDRI). The authors would like to acknowledge the ONDRI Founding Authors: Robert Bartha, Sandra E. Black, Michael Borrie, Dale Corbett, Elizabeth Finger, Morris Freedman, Barry Greenberg, Robert A. Hegele, Chris Hudson, William E. McIlroy, Manuel Montero-Odasso, David G. Munoz, Douglas P. Munoz, Michael J. Strong, Richard H. Swartz, Sean Symons, Maria Carmela Tartaglia, and Lorne Zinman.
Funding Information:
Dr. Masellis reports grants from Canadian Institutes of Health Research, during the conduct of the study; other from Associate Editor, Current Pharmacogenomics and Personalized Medicine, personal fees from Bioscape Medical Imaging CRO, personal fees from GE Healthcare, personal fees from UCB, grants from Canadian Institutes of Health Research, grants from Early Researcher Award, Ministry of Economic Development and Innovation of Ontario, grants from Ontario Brain Institute, grants from Sunnybrook AFP Innovation Fund, grants from Alzheimer’s Drug Discovery Foundation (ADDF), grants from Brain Canada, grants from Heart and Stroke Foundation Centre for Stroke Recovery, grants from Weston Brain Institute, personal fees from Novartis, personal fees from Henry Stewart Talks, other from Novartis, grants from Roche, grants from Washington University, grants from Teva, other from Teva, outside the submitted work. Dr. Lang reports personal fees from AbbVie, personal fees from Acorda, personal fees from BristolMyers Squib, personal fees from Biogen, personal fees from Merck, personal fees from Sun Pharma, personal fees from Corticobasal Solutions, personal fees from Sunovion, personal fees from Paladin, personal fees from Medichem, personal fees from Medtronic, outside the submitted work.
Funding Information:
The authors wish to thank Dr. Ellen Bialystok for valuable discussions and consultation. This research was conducted with the support of the Ontario Brain Institute, an independent non-profit corporation, funded partially by the Ontario government. The opinions, results, and conclusions are those of the authors and no endorsement by the Ontario Brain Institute is intended or should be inferred. Matching funds were provided by participant hospital and research institute foundations, including the Baycrest Foundation, Bruyère Research Institute, Centre for Addiction and Mental Health Foundation, London Health Sciences Foundation, McMaster University Faculty of Health Sciences, Ottawa Brain and Mind Research Institute, Queen’s University Faculty of Health Sciences, the Thunder Bay Regional Health Sciences Centre, the University of Ottawa Faculty of Medicine, and the Windsor/Essex County ALS Association. The Temerty Family Foundation provided the major infrastructure matching funds.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Some studies have found that bilingualism promotes cognitive reserve. Objective: We aimed to determine whether bilingualism, defined as regularly (i.e. daily) using at least two languages at least since early adulthood, is associated with cognitive advantages in Parkinson’s disease (PD) or whether the possible benefits of bilingualism are lost in the context of PD, possibly affecting quality of life (QoL) and independence. Method: Participants with idiopathic PD (n = 140, mean age = 67.9 [SD = 6.4], 78% men) completed standard neuropsychological tasks evaluating attention/working memory, language, executive function, memory, and visuospatial ability, as well as measures of wellbeing and functional independence. Results: Bilinguals with PD (n = 21) performed worse than monolinguals with PD (n = 92) on attention/working memory and language measures. The between-group differences in attention/working memory were restricted to verbally-based measures. When measured along a continuum, a higher degree of bilingualism was correlated with lower scores on measures of attention/working memory and language. There were no group differences in self- or informant-reported cognitive decline, PD health-related QoL, or functional independence. Conclusions: Bilingualism in PD was not associated with better cognitive performance. Lower scores on language-based measures may reflect a distributed fund of linguistic information across more than one language, lower language proficiency in English, and/or other cultural artifacts. Furthermore, using normative data specific to the dominant language spoken or conducting neuropsychological testing in participants’ self-reported most proficient language may enhance additional studies addressing this topic. Future research may also examine the roles of bilingualism over time and across other neurodegenerative diseases with and without EF impairment to illuminate further the impact of bilingualism on cognition and QoL, and shape culturally and linguistically diverse research and clinical care.
AB - Some studies have found that bilingualism promotes cognitive reserve. Objective: We aimed to determine whether bilingualism, defined as regularly (i.e. daily) using at least two languages at least since early adulthood, is associated with cognitive advantages in Parkinson’s disease (PD) or whether the possible benefits of bilingualism are lost in the context of PD, possibly affecting quality of life (QoL) and independence. Method: Participants with idiopathic PD (n = 140, mean age = 67.9 [SD = 6.4], 78% men) completed standard neuropsychological tasks evaluating attention/working memory, language, executive function, memory, and visuospatial ability, as well as measures of wellbeing and functional independence. Results: Bilinguals with PD (n = 21) performed worse than monolinguals with PD (n = 92) on attention/working memory and language measures. The between-group differences in attention/working memory were restricted to verbally-based measures. When measured along a continuum, a higher degree of bilingualism was correlated with lower scores on measures of attention/working memory and language. There were no group differences in self- or informant-reported cognitive decline, PD health-related QoL, or functional independence. Conclusions: Bilingualism in PD was not associated with better cognitive performance. Lower scores on language-based measures may reflect a distributed fund of linguistic information across more than one language, lower language proficiency in English, and/or other cultural artifacts. Furthermore, using normative data specific to the dominant language spoken or conducting neuropsychological testing in participants’ self-reported most proficient language may enhance additional studies addressing this topic. Future research may also examine the roles of bilingualism over time and across other neurodegenerative diseases with and without EF impairment to illuminate further the impact of bilingualism on cognition and QoL, and shape culturally and linguistically diverse research and clinical care.
KW - Bilingualism
KW - Parkinson disease
KW - cognition
KW - executive function
KW - language
KW - neuropsychological tests
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85104061575&partnerID=8YFLogxK
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U2 - 10.1080/13803395.2021.1902946
DO - 10.1080/13803395.2021.1902946
M3 - Article
C2 - 33827353
AN - SCOPUS:85104061575
SN - 1380-3395
VL - 43
SP - 199
EP - 212
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 2
ER -