Biliary response to glucagon in humans

Gene D. Branum, Bert A. Bowers, Christopher R. Watters, Jon Haebig, Giovanni Cucchiaro, Marwan Farouk, William C. Meyers

Research output: Contribution to journalArticlepeer-review

Abstract

Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid Chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalAnnals of surgery
Volume213
Issue number4
DOIs
StatePublished - Apr 1991
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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