Biliary response to glucagon in humans

Gene D. Branum; Bert A. Bowers; Christopher R. Watters; Jon Haebig; Giovanni Cucchiaro; Marwan Farouk; William C. Meyers

doi:10.1097/00000658-199104000-00008

Biliary response to glucagon in humans

Gene D. Branum, Bert A. Bowers, Christopher R. Watters, Jon Haebig, Giovanni Cucchiaro, Marwan Farouk, William C. Meyers

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid Chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.

Original language	English (US)
Pages (from-to)	335-340
Number of pages	6
Journal	Annals of surgery
Volume	213
Issue number	4
DOIs	https://doi.org/10.1097/00000658-199104000-00008
State	Published - Apr 1991
Externally published	Yes

ASJC Scopus subject areas

Surgery

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title = "Biliary response to glucagon in humans",

abstract = "Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid Chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.",

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AU - Branum, Gene D.

AU - Bowers, Bert A.

AU - Watters, Christopher R.

AU - Haebig, Jon

AU - Cucchiaro, Giovanni

AU - Farouk, Marwan

AU - Meyers, William C.

PY - 1991/4

Y1 - 1991/4

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AB - Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid Chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.

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Biliary response to glucagon in humans

Abstract

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