Biliary manometry in swine

A unique endoscopic model for teaching and research

Research output: Contribution to journalArticle

Abstract

Biliary manometry, the 'gold standard' for the diagnosis of sphincter of Oddi dysfunction, is associated with technical and methodological problems. The lack of a suitable experimental model has hindered efforts to solve these problems. We report here on the first practical animal model for endoscopic biliary manometry, similar in technique to the procedure in humans. Piglets were sedated and intubated with a standard human duodenoscope. A standard water-perfused manometry catheter was inserted into the bile duct. The biliary sphincter was identified by a zone of high-pressure activity with superimposed phasic contractions. The sphincter responded normally to the administration of cholecystokinin and morphine by relaxation and contraction respectively. This model should be useful for training in biliary manometry, and facilitate technical innovations in the field. Since it is relatively atraumatic, it may also be better than existing surgical models for studying the normal physiology and pharmacology of the sphincter of Oddi.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalEndoscopy
Volume27
Issue number1
StatePublished - 1995

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Manometry
Teaching
Swine
Research
Duodenoscopes
Sphincter of Oddi Dysfunction
Sphincter of Oddi
Anatomic Models
Cholecystokinin
Bile Ducts
Morphine
Theoretical Models
Catheters
Animal Models
Pharmacology
Pressure
Water

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Biliary manometry in swine : A unique endoscopic model for teaching and research. / Pasricha, Pankaj Jay; Tietjen, T. G.; Kalloo, Anthony N.

In: Endoscopy, Vol. 27, No. 1, 1995, p. 70-72.

Research output: Contribution to journalArticle

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