Biliary excretion of platinum in rats after administration of cisplatin and aqua(1,1-bis(aminomethyl)-cyclohexane)sulfatoplatinum(II) (Spiroplatin, TNO-6)

W. J F van der Vijgh, P. C M Verbeek, I. Klein, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

Three groups of 6 rats were treated with cisplatin (3 mg/kg, bolus and 3-h infusion) and spiroplatin (3 mg/kg, bolus) by infusion in the right external jugular vein. The mean amounts of platinum ± c.v. excreted in the bile during the first 6 h after the start of administration were 0.32 ± 0.19% and 0.39 ± 0.29% of the dose after bolus injection and 3-h infusion of cisplatin, respectively, and 3.77 ± 3.32% of the dose after spiroplatin. The values were not significantly different between the 2 cisplatin administration modes (P > 0.05), but were between the spiroplatin and cisplatin bolus groups (Wilcoxon two-sided rank test, P <0.01). These data are related to pharmacokinetic parameters in man.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCancer Letters
Volume28
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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