Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis

S. K. Dutta, K. Anand, T. R. Gadacz

Research output: Contribution to journalArticle

Abstract

Twenty patients with exocrine pancreatic insufficiency secondary to alcohol abuse were studied for the presence of bile salt malabsorption. Fecal bile salts and fecal fat excretion were determined in 15 patients receiving pancreatic enzyme therapy, not receiving enzyme therapy, and on a regimen of pancreatic enzymes plus cimetidine. Serum bile salt levels were measured during fasting and postprandial conditions both during enzyme therapy and after it was stopped in 8 cases. In addition, 5 patients underwent [14C]cholylglycine breath testing during and after discontinuation of enzyme therapy. The fecal bile salt excretion varied between 610 and 3460 mg/day in the untreated patients. Treatment with pancreatic enzymes was associated with significant (p <0.05) reduction in fecal bile salt and fecal fat excretion. Cimetidine therapy in addition to enzyme therapy further reduced steatorrhea but failed to alter bile salt excretion significantly. Serum cholylglycine level showed significant (p <0.05) postprandial increase in patients receiving enzyme therapy, suggesting improved bile salt absorption. These data suggest a wide range of bile salt malabsorption in alcoholic patients with pancreatic insufficiency, which improves with pancreatic enzyme therapy.

Original languageEnglish (US)
Pages (from-to)1243-1249
Number of pages7
JournalGastroenterology
Volume91
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Alcoholic Pancreatitis
Exocrine Pancreatic Insufficiency
Enzyme Therapy
Bile Acids and Salts
Glycocholic Acid
Cimetidine
Fats
Steatorrhea
Enzymes
Alcoholics
Serum
Alcoholism
Fasting

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Dutta, S. K., Anand, K., & Gadacz, T. R. (1986). Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis. Gastroenterology, 91(5), 1243-1249.

Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis. / Dutta, S. K.; Anand, K.; Gadacz, T. R.

In: Gastroenterology, Vol. 91, No. 5, 1986, p. 1243-1249.

Research output: Contribution to journalArticle

Dutta, SK, Anand, K & Gadacz, TR 1986, 'Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis', Gastroenterology, vol. 91, no. 5, pp. 1243-1249.
Dutta, S. K. ; Anand, K. ; Gadacz, T. R. / Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis. In: Gastroenterology. 1986 ; Vol. 91, No. 5. pp. 1243-1249.
@article{f177f1539743420a95ac1904ff59c13e,
title = "Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis",
abstract = "Twenty patients with exocrine pancreatic insufficiency secondary to alcohol abuse were studied for the presence of bile salt malabsorption. Fecal bile salts and fecal fat excretion were determined in 15 patients receiving pancreatic enzyme therapy, not receiving enzyme therapy, and on a regimen of pancreatic enzymes plus cimetidine. Serum bile salt levels were measured during fasting and postprandial conditions both during enzyme therapy and after it was stopped in 8 cases. In addition, 5 patients underwent [14C]cholylglycine breath testing during and after discontinuation of enzyme therapy. The fecal bile salt excretion varied between 610 and 3460 mg/day in the untreated patients. Treatment with pancreatic enzymes was associated with significant (p <0.05) reduction in fecal bile salt and fecal fat excretion. Cimetidine therapy in addition to enzyme therapy further reduced steatorrhea but failed to alter bile salt excretion significantly. Serum cholylglycine level showed significant (p <0.05) postprandial increase in patients receiving enzyme therapy, suggesting improved bile salt absorption. These data suggest a wide range of bile salt malabsorption in alcoholic patients with pancreatic insufficiency, which improves with pancreatic enzyme therapy.",
author = "Dutta, {S. K.} and K. Anand and Gadacz, {T. R.}",
year = "1986",
language = "English (US)",
volume = "91",
pages = "1243--1249",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis

AU - Dutta, S. K.

AU - Anand, K.

AU - Gadacz, T. R.

PY - 1986

Y1 - 1986

N2 - Twenty patients with exocrine pancreatic insufficiency secondary to alcohol abuse were studied for the presence of bile salt malabsorption. Fecal bile salts and fecal fat excretion were determined in 15 patients receiving pancreatic enzyme therapy, not receiving enzyme therapy, and on a regimen of pancreatic enzymes plus cimetidine. Serum bile salt levels were measured during fasting and postprandial conditions both during enzyme therapy and after it was stopped in 8 cases. In addition, 5 patients underwent [14C]cholylglycine breath testing during and after discontinuation of enzyme therapy. The fecal bile salt excretion varied between 610 and 3460 mg/day in the untreated patients. Treatment with pancreatic enzymes was associated with significant (p <0.05) reduction in fecal bile salt and fecal fat excretion. Cimetidine therapy in addition to enzyme therapy further reduced steatorrhea but failed to alter bile salt excretion significantly. Serum cholylglycine level showed significant (p <0.05) postprandial increase in patients receiving enzyme therapy, suggesting improved bile salt absorption. These data suggest a wide range of bile salt malabsorption in alcoholic patients with pancreatic insufficiency, which improves with pancreatic enzyme therapy.

AB - Twenty patients with exocrine pancreatic insufficiency secondary to alcohol abuse were studied for the presence of bile salt malabsorption. Fecal bile salts and fecal fat excretion were determined in 15 patients receiving pancreatic enzyme therapy, not receiving enzyme therapy, and on a regimen of pancreatic enzymes plus cimetidine. Serum bile salt levels were measured during fasting and postprandial conditions both during enzyme therapy and after it was stopped in 8 cases. In addition, 5 patients underwent [14C]cholylglycine breath testing during and after discontinuation of enzyme therapy. The fecal bile salt excretion varied between 610 and 3460 mg/day in the untreated patients. Treatment with pancreatic enzymes was associated with significant (p <0.05) reduction in fecal bile salt and fecal fat excretion. Cimetidine therapy in addition to enzyme therapy further reduced steatorrhea but failed to alter bile salt excretion significantly. Serum cholylglycine level showed significant (p <0.05) postprandial increase in patients receiving enzyme therapy, suggesting improved bile salt absorption. These data suggest a wide range of bile salt malabsorption in alcoholic patients with pancreatic insufficiency, which improves with pancreatic enzyme therapy.

UR - http://www.scopus.com/inward/record.url?scp=0022480533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022480533&partnerID=8YFLogxK

M3 - Article

C2 - 3758616

AN - SCOPUS:0022480533

VL - 91

SP - 1243

EP - 1249

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5

ER -