TY - JOUR
T1 - Bilateral optic neuropathy associated with the tumor necrosis factor-alpha inhibitor golimumab
AU - Chang, Jessica R.
AU - Miller, Neil R.
N1 - Publisher Copyright:
© 2014 by North American Neuro-Ophthalmology Society.
PY - 2014/12/8
Y1 - 2014/12/8
N2 - A 62-year-old man developed bilateral blurred vision associated with bilateral optic disc swelling shortly after receiving his third dose of the tumor necrosis factor-alpha (TNF-α) inhibitor golimumab, that he took for psoriatic arthritis. An extensive assessment including magnetic resonance imaging, lumbar puncture, and serologies was negative. He was treated with systemic corticosteroids and the golimumab was stopped, after which his vision improved and his disc swelling resolved. We postulate that the bilateral, simultaneous anterior optic neuropathies in this patient were due to golimumab, representing a rare but well-documented serious adverse event associated with TNF-α inhibitors.
AB - A 62-year-old man developed bilateral blurred vision associated with bilateral optic disc swelling shortly after receiving his third dose of the tumor necrosis factor-alpha (TNF-α) inhibitor golimumab, that he took for psoriatic arthritis. An extensive assessment including magnetic resonance imaging, lumbar puncture, and serologies was negative. He was treated with systemic corticosteroids and the golimumab was stopped, after which his vision improved and his disc swelling resolved. We postulate that the bilateral, simultaneous anterior optic neuropathies in this patient were due to golimumab, representing a rare but well-documented serious adverse event associated with TNF-α inhibitors.
UR - http://www.scopus.com/inward/record.url?scp=84916202135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916202135&partnerID=8YFLogxK
U2 - 10.1097/WNO.0000000000000137
DO - 10.1097/WNO.0000000000000137
M3 - Article
C2 - 25259862
AN - SCOPUS:84916202135
SN - 1070-8022
VL - 34
SP - 336
EP - 339
JO - Journal of Neuro-Ophthalmology
JF - Journal of Neuro-Ophthalmology
IS - 4
ER -