Bilateral diaphragm paralysis secondary to central von Recklinghausen's disease

Paul M. Hassoun, Bartolome R. Celli

Research output: Contribution to journalArticle

Abstract

Bilateral paralysis of the diaphragm is either idiopathic or associated with several medical conditions, including trauma or thoracic surgery, viral infections, and neurologic congenital or degenerative disorders. We describe the case of a 36-year-old man with a history of neurofibromatosis who developed severe bilateral diaphragmatic paralysis from involvement of the phrenic nerve roots with neurofibromas. The patient manifested progressive exertional dyspnea and debilitating orthopnea requiring the use of noninvasive mechanical ventilation at night. A review of the literature reveals that neurofibromatosis is an unrecognized cause of diaphragmatic paralysis.

Original languageEnglish (US)
Pages (from-to)1196-1199
Number of pages4
JournalCHEST
Volume117
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Diaphragm dysfunction
  • Neurofibromatosis
  • Phrenic nerve
  • Respiratory failure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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