Bilateral adrenocortical carcinoma showing loss of heterozygosity at the p53 and RB gene loci

Hiroshi Miyamoto, Yoshinobu Kubota, Taro Shuin, Hiroshi Shiozaki

Research output: Contribution to journalArticle


Presented is a rare case of nonfamilial, hormonally nonfunctional adrenocortical carcinoma with synchronous bilateral adrenal involvement. We investigated adrenal and metastatic tumors for loss of heterozygosity affecting four genetic loci containing the tumor suppressor genes p53, RB, DCC, and APC, using polymerase chain reaction and restriction fragment length polymorphism assay. Allelic losses at the p53 and RB loci were detected in all tumor samples, suggesting that the p53 and RB genes are involved in the tumorigenesis of adrenocortical carcinoma.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Jun 1996


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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