TY - JOUR
T1 - Bilateral adrenocortical carcinoma showing loss of heterozygosity at the p53 and RB gene loci
AU - Miyamoto, Hiroshi
AU - Kubota, Yoshinobu
AU - Shuin, Taro
AU - Shiozaki, Hiroshi
PY - 1996/6
Y1 - 1996/6
N2 - Presented is a rare case of nonfamilial, hormonally nonfunctional adrenocortical carcinoma with synchronous bilateral adrenal involvement. We investigated adrenal and metastatic tumors for loss of heterozygosity affecting four genetic loci containing the tumor suppressor genes p53, RB, DCC, and APC, using polymerase chain reaction and restriction fragment length polymorphism assay. Allelic losses at the p53 and RB loci were detected in all tumor samples, suggesting that the p53 and RB genes are involved in the tumorigenesis of adrenocortical carcinoma.
AB - Presented is a rare case of nonfamilial, hormonally nonfunctional adrenocortical carcinoma with synchronous bilateral adrenal involvement. We investigated adrenal and metastatic tumors for loss of heterozygosity affecting four genetic loci containing the tumor suppressor genes p53, RB, DCC, and APC, using polymerase chain reaction and restriction fragment length polymorphism assay. Allelic losses at the p53 and RB loci were detected in all tumor samples, suggesting that the p53 and RB genes are involved in the tumorigenesis of adrenocortical carcinoma.
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U2 - 10.1016/0165-4608(95)00292-8
DO - 10.1016/0165-4608(95)00292-8
M3 - Article
C2 - 8640732
AN - SCOPUS:0029887350
SN - 0165-4608
VL - 88
SP - 181
EP - 183
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -