TY - JOUR
T1 - Bicarbonate versus citrate in oral rehydration therapy in infants with watery diarrhea
T2 - A controlled clinical trial
AU - Salazar-Lindo, Eduardo
AU - Sack, R. Bradley
AU - Chea-Woo, Elsa
AU - Leon-Barua, Raul
AU - Kay, Bradford A.
AU - Yi, Augusto
AU - Robertson, Alastair D.
N1 - Funding Information:
Presented in part at the 1 lth International Congress for Tropical Medicine and Malaria, Calgary, Alberta, Canada, September 16 tO 22, 1984. Supported by grants from the World Health Organization and Nesi~16 Coordination Center for Nutrition, Inc. Submitted for publication Feb. 12, 1985;a ccepted June 20, 1985. Reprint requests: R. Bradley Sack, M.D., Sc.D., Francis Scott Key Medical Center, G Bldg., Rm. 128, Baltimore, MD 21224.
PY - 1986/1
Y1 - 1986/1
N2 - In a double-blind, ramdomized trial, we compared the efficacy of bicarbonate-containing oral rehydration solution vs citrate-containing solution in the treatment of infantile diarrheal dehydration and acidosis. Ninety-seven infants 3 to 24 months of age were entered in the study; 49 received bicarbonate-containing solution and 48 citrate-containing solution. The two groups were similar in all respects at the beginning of the study. Oral rehydration was successful (i.e., no intravenously administered fluids were required) in 85% of study patients; the success rate was similar in both treatment groups. Serum total CO2 concentration increased in a similar fashion in both groups, reaching near normal values at 48 hours after admission. We conclude that sodium citrate can be substituted for sodium bicarbonate in the formulation of the orally administered rehydration solution recommended by the World Health Organization for treatment of diarrheal dehydration in infants.
AB - In a double-blind, ramdomized trial, we compared the efficacy of bicarbonate-containing oral rehydration solution vs citrate-containing solution in the treatment of infantile diarrheal dehydration and acidosis. Ninety-seven infants 3 to 24 months of age were entered in the study; 49 received bicarbonate-containing solution and 48 citrate-containing solution. The two groups were similar in all respects at the beginning of the study. Oral rehydration was successful (i.e., no intravenously administered fluids were required) in 85% of study patients; the success rate was similar in both treatment groups. Serum total CO2 concentration increased in a similar fashion in both groups, reaching near normal values at 48 hours after admission. We conclude that sodium citrate can be substituted for sodium bicarbonate in the formulation of the orally administered rehydration solution recommended by the World Health Organization for treatment of diarrheal dehydration in infants.
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U2 - 10.1016/S0022-3476(86)80768-5
DO - 10.1016/S0022-3476(86)80768-5
M3 - Article
C2 - 3003317
AN - SCOPUS:0022621603
SN - 0022-3476
VL - 108
SP - 55
EP - 60
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 1
ER -