Bicarbonate versus citrate in oral rehydration therapy in infants with watery diarrhea: A controlled clinical trial

Eduardo Salazar-Lindo, R. Bradley Sack, Elsa Chea-Woo, Raul Leon-Barua, Bradford A. Kay, Augusto Yi, Alastair D. Robertson

Research output: Contribution to journalArticlepeer-review

Abstract

In a double-blind, ramdomized trial, we compared the efficacy of bicarbonate-containing oral rehydration solution vs citrate-containing solution in the treatment of infantile diarrheal dehydration and acidosis. Ninety-seven infants 3 to 24 months of age were entered in the study; 49 received bicarbonate-containing solution and 48 citrate-containing solution. The two groups were similar in all respects at the beginning of the study. Oral rehydration was successful (i.e., no intravenously administered fluids were required) in 85% of study patients; the success rate was similar in both treatment groups. Serum total CO2 concentration increased in a similar fashion in both groups, reaching near normal values at 48 hours after admission. We conclude that sodium citrate can be substituted for sodium bicarbonate in the formulation of the orally administered rehydration solution recommended by the World Health Organization for treatment of diarrheal dehydration in infants.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalThe Journal of pediatrics
Volume108
Issue number1
DOIs
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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