Biased excitable networks

How cells direct motion in response to gradients

Research output: Contribution to journalArticle

Abstract

The actin cytoskeleton in motile cells has many of the hallmarks of an excitable medium, including the presence of propagating waves. This excitable behavior can account for the spontaneous migration of cells. A number of reports have suggested that the chemoattractant-mediated signaling can bias excitability, thus providing a means by which cell motility can be directed. In this review, we discuss some of these observations and theories proposed to explain them. We also suggest a mechanism for cell polarity that can be incorporated into the existing framework.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume24
Issue number2
DOIs
StatePublished - Apr 2012

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Cell Movement
Cell Polarity
Chemotactic Factors
Actin Cytoskeleton

ASJC Scopus subject areas

  • Cell Biology

Cite this

Biased excitable networks : How cells direct motion in response to gradients. / Iglesias, Pablo A; Devreotes, Peter N.

In: Current Opinion in Cell Biology, Vol. 24, No. 2, 04.2012, p. 245-253.

Research output: Contribution to journalArticle

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