TY - JOUR
T1 - Beyond the looking glass
T2 - recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
AU - Hollander, Jonathan A.
AU - Cory-Slechta, Deborah A.
AU - Jacka, Felice N.
AU - Szabo, Steven T.
AU - Guilarte, Tomás R.
AU - Bilbo, Staci D.
AU - Mattingly, Carolyn J.
AU - Moy, Sheryl S.
AU - Haroon, Ebrahim
AU - Hornig, Mady
AU - Levin, Edward D.
AU - Pletnikov, Mikhail V.
AU - Zehr, Julia L.
AU - McAllister, Kimberly A.
AU - Dzierlenga, Anika L.
AU - Garton, Amanda E.
AU - Lawler, Cindy P.
AU - Ladd-Acosta, Christine
N1 - Funding Information:
This work was supported in part by the NIH, National Institute of Environmental Health Sciences (to JA Hollander, KA McAllister, AL Dzierlenga, AE Garton, CP Lawler) and National Institute of Mental Health (to JL Zehr), the NIH grants: R01ES014065 and P30ES025128 (to CJ Mattingly); R01ES06189 (to TR Guilarte); R01HD090051 (to M Hornig); U54HD079124 (to SS Moy); and the U.S. Department of Veterans Affairs grant IK2CX001397 (to ST Szabo). FN Jacka has received Grant/Research support from the Brain and Behavior Research Institute, the National Health and Medical Research Council (NHMRC), Australian Rotary Health, the Geelong Medical Research Foundation, the Ian Potter Foundation, Eli Lilly, Meat and Livestock Australia, Woolworths Limited, Fernwood Gyms, The Wilson Foundation, The A2 Milk Company, The University of Melbourne and has received speakers honoraria from Sanofi-Synthelabo, Janssen Cilag, Servier, Pfizer, Health Ed, Network Nutrition, Angelini Farmaceutica, Eli Lilly and Metagenics. FN Jacka has written two books for commercial publication that promotes the idea that good diet quality is important for mental and brain health. The views expressed in this review are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States Government. The remaining authors declare no competing interests.
Publisher Copyright:
© 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. This article is published with open access.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms—synaptic dysfunction, immune alterations, and gut–brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease.
AB - The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms—synaptic dysfunction, immune alterations, and gut–brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease.
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U2 - 10.1038/s41386-020-0648-5
DO - 10.1038/s41386-020-0648-5
M3 - Review article
C2 - 32109936
AN - SCOPUS:85081889640
VL - 45
SP - 1086
EP - 1096
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 7
ER -