Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis

A. L. Sutterland, G. Fond, A. Kuin, M. W J Koeter, R. Lutter, T. van Gool, Robert H Yolken, A. Szoke, M. Leboyer, L. de Haan

Research output: Contribution to journalArticle

Abstract

Objective: To perform a meta-analysis on studies reporting prevalence of Toxoplasma gondii (T. gondii) infection in any psychiatric disorder compared with healthy controls. Our secondary objective was to analyze factors possibly moderating heterogeneity. Method: A systematic search was performed to identify studies into T. gondii infection for all major psychiatric disorders versus healthy controls. Methodological quality, publication bias, and possible moderators were assessed. Results: A total of 2866 citations were retrieved and 50 studies finally included. Significant odds ratios (ORs) with IgG antibodies were found in schizophrenia (OR 1.81, P <0.00001), bipolar disorder (OR 1.52, P = 0.02), obsessive-compulsive disorder (OR 3.4, P <0.001), and addiction (OR 1.91, P <0.00001), but not for major depression (OR 1.21, P = 0.28). Exploration of the association between T. gondii and schizophrenia yielded a significant effect of seropositivity before onset and serointensity, but not IgM antibodies or gender. The amplitude of the OR was influenced by region and general seroprevalence. Moderators together accounted for 56% of the observed variance in study effects. After controlling for publication bias, the adjusted OR (1.43) in schizophrenia remained significant. Conclusion: These findings suggest that T. gondii infection is associated with several psychiatric disorders and that in schizophrenia reactivation of latent T. gondii infection may occur.

Original languageEnglish (US)
Pages (from-to)161-179
Number of pages19
JournalActa Psychiatrica Scandinavica
Volume132
Issue number3
DOIs
StatePublished - Sep 1 2015

Fingerprint

Toxoplasma
Bipolar Disorder
Meta-Analysis
Schizophrenia
Odds Ratio
Toxoplasmosis
Psychiatry
Publication Bias
Schizotypal Personality Disorder
Antibodies
Obsessive-Compulsive Disorder
Seroepidemiologic Studies
Statistical Factor Analysis
Immunoglobulin M
Cross-Sectional Studies
Immunoglobulin G
Depression

Keywords

  • Toxoplasma gondii
  • Bipolar disorder
  • Meta-analysis
  • Schizophrenia
  • Substance abuse disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sutterland, A. L., Fond, G., Kuin, A., Koeter, M. W. J., Lutter, R., van Gool, T., ... de Haan, L. (2015). Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis. Acta Psychiatrica Scandinavica, 132(3), 161-179. https://doi.org/10.1111/acps.12423

Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction : Systematic review and meta-analysis. / Sutterland, A. L.; Fond, G.; Kuin, A.; Koeter, M. W J; Lutter, R.; van Gool, T.; Yolken, Robert H; Szoke, A.; Leboyer, M.; de Haan, L.

In: Acta Psychiatrica Scandinavica, Vol. 132, No. 3, 01.09.2015, p. 161-179.

Research output: Contribution to journalArticle

Sutterland, AL, Fond, G, Kuin, A, Koeter, MWJ, Lutter, R, van Gool, T, Yolken, RH, Szoke, A, Leboyer, M & de Haan, L 2015, 'Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis', Acta Psychiatrica Scandinavica, vol. 132, no. 3, pp. 161-179. https://doi.org/10.1111/acps.12423
Sutterland, A. L. ; Fond, G. ; Kuin, A. ; Koeter, M. W J ; Lutter, R. ; van Gool, T. ; Yolken, Robert H ; Szoke, A. ; Leboyer, M. ; de Haan, L. / Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction : Systematic review and meta-analysis. In: Acta Psychiatrica Scandinavica. 2015 ; Vol. 132, No. 3. pp. 161-179.
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