TY - JOUR
T1 - Beyond parallel fiber LTD
T2 - The diversity of synaptic and non-synaptic plasticity in the cerebellum
AU - Hansel, Christian
AU - Linden, David J.
AU - D'Angelo, Egidio
N1 - Funding Information:
This work was supported by NWO-ALW 810.37.003 (C.H.), USPHS MH01590, MH51106, MH61974 and the Develbiss Fund (D.J.L.) and EC grants PL97 0182 and PL97 6060, and INFM PRA-Cady (E.D.). We thank C. De Zeeuw, M. Mauk, M. Schmolesky and J. Weber for comments.
PY - 2001
Y1 - 2001
N2 - In recent years, it has become clear that motor learning, as revealed by associative eyelid conditioning and adaptation of the vestibulo-ocular reflex, contributes to the well-established cerebellar functions of sensorimotor integration and control. Long-term depression of the parallel fiber-Purkinje cell synapse (which is often called 'cerebellar LTD') is a cellular phenomenon that has been suggested to underlie these forms of learning. However, it is clear that parallel fiber LTD, by itself, cannot account for all the properties of cerebellar motor learning. Here we review recent electrophysiological experiments that have described a rich variety of use-dependent plasticity in cerebellum, including long-term potentiation (LTP) and LTD of excitatory and inhibitory synapses, and persistent modulation of intrinsic neuronal excitability. Finally, using associative eyelid conditioning as an example, we propose some ideas about how these cellular phenomena might function and interact to endow the cerebellar circuit with particular computational and mnemonic properties.
AB - In recent years, it has become clear that motor learning, as revealed by associative eyelid conditioning and adaptation of the vestibulo-ocular reflex, contributes to the well-established cerebellar functions of sensorimotor integration and control. Long-term depression of the parallel fiber-Purkinje cell synapse (which is often called 'cerebellar LTD') is a cellular phenomenon that has been suggested to underlie these forms of learning. However, it is clear that parallel fiber LTD, by itself, cannot account for all the properties of cerebellar motor learning. Here we review recent electrophysiological experiments that have described a rich variety of use-dependent plasticity in cerebellum, including long-term potentiation (LTP) and LTD of excitatory and inhibitory synapses, and persistent modulation of intrinsic neuronal excitability. Finally, using associative eyelid conditioning as an example, we propose some ideas about how these cellular phenomena might function and interact to endow the cerebellar circuit with particular computational and mnemonic properties.
UR - http://www.scopus.com/inward/record.url?scp=0035029611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035029611&partnerID=8YFLogxK
U2 - 10.1038/87419
DO - 10.1038/87419
M3 - Review article
C2 - 11319554
AN - SCOPUS:0035029611
SN - 1097-6256
VL - 4
SP - 467
EP - 475
JO - Nature neuroscience
JF - Nature neuroscience
IS - 5
ER -