TY - JOUR
T1 - Beyond gastric emptying
T2 - A "toxic" lesson about gastroparesis
AU - Pasricha, Pankaj J.
PY - 2008/2/1
Y1 - 2008/2/1
N2 - The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. In this editorial, I discuss the limitations and implications of this study, with particular emphasis on what the use of botulinum toxin can teach us about the pathophysiology of gastroparesis and other gastrointestinal smooth muscle disorders.
AB - The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. In this editorial, I discuss the limitations and implications of this study, with particular emphasis on what the use of botulinum toxin can teach us about the pathophysiology of gastroparesis and other gastrointestinal smooth muscle disorders.
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U2 - 10.1111/j.1572-0241.2007.01672.x
DO - 10.1111/j.1572-0241.2007.01672.x
M3 - Review article
C2 - 18289204
AN - SCOPUS:39049096671
SN - 0002-9270
VL - 103
SP - 424
EP - 426
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 2
ER -