Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?

Carla Coltharp, Jie Xiao

Research output: Contribution to journalArticle

Abstract

We propose that the essential function of the most highly conserved protein in bacterial cytokinesis, FtsZ, is not to generate a mechanical force to drive cell division. Rather, we suggest that FtsZ acts as a signal-processing hub to coordinate cell wall synthesis at the division septum with a diverse array of cellular processes, ensuring that the cell divides smoothly at the correct time and place, and with the correct septum morphology. Here, we explore how the polymerization properties of FtsZ, which have been widely attributed to force generation, can also be advantageous in this signal processing role. We suggest mechanisms by which FtsZ senses and integrates both mechanical and biochemical signals, and conclude by proposing experiments to investigate how FtsZ contributes to the remarkable spatial and temporal precision of bacterial cytokinesis.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBioEssays
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • FtsZ
  • cell division
  • cell wall synthesis
  • cytokinesis
  • cytoskeleton
  • dynamics
  • force generation
  • signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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