Beyond ergosterol: Linking ph to antifungal mechanisms

Yong Qiang Zhang, Rajini Rao

Research output: Contribution to journalArticlepeer-review

Abstract

Many antifungal drugs including the highly successful azoles target the fungal-specific sterol, ergosterol, yet the molecular identity of cellular pathways mediating antifungal activity remained obscure. A recent study on the requirement of ergosterol in vacuolar H+-ATPase (V-ATPase) function uncovered a critical role for ion homeostasis downstream of azole inhibition of ergosterol biosynthesis. Here we review the functional link between regulation of V-ATPase by fungal membrane lipid components and discuss contributions of V-ATPase function to pathogenicity. The importance of pH homeostasis in virulence highlights its potential as target in antifungal chemotherapy.

Original languageEnglish (US)
Pages (from-to)551-554
Number of pages4
JournalVirulence
Volume1
Issue number6
DOIs
StatePublished - Jul 2010

Keywords

  • Candida albicans
  • Ergosterol
  • Ph homeostasis
  • V-atpase
  • Vacuole
  • Yeast

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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