Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease

Shannon A. Johnson, Julie C. Stout, Andrea C. Solomon, Douglas R. Langbehn, Elizabeth H. Aylward, Christina B. Cruce, Christopher A Ross, Martha Nance, Elise Kayson, Elaine Julian-Baros, Michael R. Hayden, Karl Kieburtz, Mark Guttman, David Oakes, Ira Shoulson, Leigh Beglinger, Kevin Duff, Elizabeth Penziner, Jane S. Paulsen

Research output: Contribution to journalArticle

Abstract

Previous studies of emotion recognition suggest that detection of disgust relies on processing within the basal ganglia and insula. Research involving individuals with symptomatic and pre-diagnostic Huntington's disease (HD), a disease with known basal ganglia atrophy, has generally indicated a relative impairment in recognizing disgust. However, some data have suggested that recognition of other emotions (particularly fear and anger) may also be affected in HD, and a recent study found fear recognition deficits in the absence of other emotion-recognition impairments, including disgust. To further examine emotion recognition in HD, we administered a computerized facial emotion recognition task to 475 individuals with the HD CAG expansion and 57 individuals without. Logistic regression was used to examine associations of emotion recognition performance with estimated proximity to clinical diagnosis (based on CAG repeat length and current age) and striatal volumes. Recognition of anger, disgust, fear, sadness and surprise (but not happiness) was associated with estimated years to clinical diagnosis; performance was unrelated to striatal volumes. Compared to a CAG-normal control group, the CAG-expanded group demonstrated significantly less accurate recognition of all negative emotions (anger, disgust, fear, sadness). Additionally, participants with more pronounced motor signs of HD were significantly less accurate at recognizing negative emotions than were individuals with fewer motor signs. Findings indicate that recognition of all negative emotions declines early in the disease process, and poorer performance is associated with closer proximity to clinical diagnosis. In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.

Original languageEnglish (US)
Pages (from-to)1732-1744
Number of pages13
JournalBrain
Volume130
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Huntington Disease
Emotions
Fear
Anger
Corpus Striatum
Basal Ganglia
Happiness
Atrophy
Logistic Models
Control Groups

Keywords

  • Disgust
  • Emotion recognition
  • Predict-HD
  • Presymptomatic Huntington's disease
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Johnson, S. A., Stout, J. C., Solomon, A. C., Langbehn, D. R., Aylward, E. H., Cruce, C. B., ... Paulsen, J. S. (2007). Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain, 130(7), 1732-1744. https://doi.org/10.1093/brain/awm107

Beyond disgust : Impaired recognition of negative emotions prior to diagnosis in Huntington's disease. / Johnson, Shannon A.; Stout, Julie C.; Solomon, Andrea C.; Langbehn, Douglas R.; Aylward, Elizabeth H.; Cruce, Christina B.; Ross, Christopher A; Nance, Martha; Kayson, Elise; Julian-Baros, Elaine; Hayden, Michael R.; Kieburtz, Karl; Guttman, Mark; Oakes, David; Shoulson, Ira; Beglinger, Leigh; Duff, Kevin; Penziner, Elizabeth; Paulsen, Jane S.

In: Brain, Vol. 130, No. 7, 07.2007, p. 1732-1744.

Research output: Contribution to journalArticle

Johnson, SA, Stout, JC, Solomon, AC, Langbehn, DR, Aylward, EH, Cruce, CB, Ross, CA, Nance, M, Kayson, E, Julian-Baros, E, Hayden, MR, Kieburtz, K, Guttman, M, Oakes, D, Shoulson, I, Beglinger, L, Duff, K, Penziner, E & Paulsen, JS 2007, 'Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease', Brain, vol. 130, no. 7, pp. 1732-1744. https://doi.org/10.1093/brain/awm107
Johnson, Shannon A. ; Stout, Julie C. ; Solomon, Andrea C. ; Langbehn, Douglas R. ; Aylward, Elizabeth H. ; Cruce, Christina B. ; Ross, Christopher A ; Nance, Martha ; Kayson, Elise ; Julian-Baros, Elaine ; Hayden, Michael R. ; Kieburtz, Karl ; Guttman, Mark ; Oakes, David ; Shoulson, Ira ; Beglinger, Leigh ; Duff, Kevin ; Penziner, Elizabeth ; Paulsen, Jane S. / Beyond disgust : Impaired recognition of negative emotions prior to diagnosis in Huntington's disease. In: Brain. 2007 ; Vol. 130, No. 7. pp. 1732-1744.
@article{17a2c7aa28dd4cb08e057167b6c85933,
title = "Beyond disgust: Impaired recognition of negative emotions prior to diagnosis in Huntington's disease",
abstract = "Previous studies of emotion recognition suggest that detection of disgust relies on processing within the basal ganglia and insula. Research involving individuals with symptomatic and pre-diagnostic Huntington's disease (HD), a disease with known basal ganglia atrophy, has generally indicated a relative impairment in recognizing disgust. However, some data have suggested that recognition of other emotions (particularly fear and anger) may also be affected in HD, and a recent study found fear recognition deficits in the absence of other emotion-recognition impairments, including disgust. To further examine emotion recognition in HD, we administered a computerized facial emotion recognition task to 475 individuals with the HD CAG expansion and 57 individuals without. Logistic regression was used to examine associations of emotion recognition performance with estimated proximity to clinical diagnosis (based on CAG repeat length and current age) and striatal volumes. Recognition of anger, disgust, fear, sadness and surprise (but not happiness) was associated with estimated years to clinical diagnosis; performance was unrelated to striatal volumes. Compared to a CAG-normal control group, the CAG-expanded group demonstrated significantly less accurate recognition of all negative emotions (anger, disgust, fear, sadness). Additionally, participants with more pronounced motor signs of HD were significantly less accurate at recognizing negative emotions than were individuals with fewer motor signs. Findings indicate that recognition of all negative emotions declines early in the disease process, and poorer performance is associated with closer proximity to clinical diagnosis. In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.",
keywords = "Disgust, Emotion recognition, Predict-HD, Presymptomatic Huntington's disease, Striatum",
author = "Johnson, {Shannon A.} and Stout, {Julie C.} and Solomon, {Andrea C.} and Langbehn, {Douglas R.} and Aylward, {Elizabeth H.} and Cruce, {Christina B.} and Ross, {Christopher A} and Martha Nance and Elise Kayson and Elaine Julian-Baros and Hayden, {Michael R.} and Karl Kieburtz and Mark Guttman and David Oakes and Ira Shoulson and Leigh Beglinger and Kevin Duff and Elizabeth Penziner and Paulsen, {Jane S.}",
year = "2007",
month = "7",
doi = "10.1093/brain/awm107",
language = "English (US)",
volume = "130",
pages = "1732--1744",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Beyond disgust

T2 - Impaired recognition of negative emotions prior to diagnosis in Huntington's disease

AU - Johnson, Shannon A.

AU - Stout, Julie C.

AU - Solomon, Andrea C.

AU - Langbehn, Douglas R.

AU - Aylward, Elizabeth H.

AU - Cruce, Christina B.

AU - Ross, Christopher A

AU - Nance, Martha

AU - Kayson, Elise

AU - Julian-Baros, Elaine

AU - Hayden, Michael R.

AU - Kieburtz, Karl

AU - Guttman, Mark

AU - Oakes, David

AU - Shoulson, Ira

AU - Beglinger, Leigh

AU - Duff, Kevin

AU - Penziner, Elizabeth

AU - Paulsen, Jane S.

PY - 2007/7

Y1 - 2007/7

N2 - Previous studies of emotion recognition suggest that detection of disgust relies on processing within the basal ganglia and insula. Research involving individuals with symptomatic and pre-diagnostic Huntington's disease (HD), a disease with known basal ganglia atrophy, has generally indicated a relative impairment in recognizing disgust. However, some data have suggested that recognition of other emotions (particularly fear and anger) may also be affected in HD, and a recent study found fear recognition deficits in the absence of other emotion-recognition impairments, including disgust. To further examine emotion recognition in HD, we administered a computerized facial emotion recognition task to 475 individuals with the HD CAG expansion and 57 individuals without. Logistic regression was used to examine associations of emotion recognition performance with estimated proximity to clinical diagnosis (based on CAG repeat length and current age) and striatal volumes. Recognition of anger, disgust, fear, sadness and surprise (but not happiness) was associated with estimated years to clinical diagnosis; performance was unrelated to striatal volumes. Compared to a CAG-normal control group, the CAG-expanded group demonstrated significantly less accurate recognition of all negative emotions (anger, disgust, fear, sadness). Additionally, participants with more pronounced motor signs of HD were significantly less accurate at recognizing negative emotions than were individuals with fewer motor signs. Findings indicate that recognition of all negative emotions declines early in the disease process, and poorer performance is associated with closer proximity to clinical diagnosis. In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.

AB - Previous studies of emotion recognition suggest that detection of disgust relies on processing within the basal ganglia and insula. Research involving individuals with symptomatic and pre-diagnostic Huntington's disease (HD), a disease with known basal ganglia atrophy, has generally indicated a relative impairment in recognizing disgust. However, some data have suggested that recognition of other emotions (particularly fear and anger) may also be affected in HD, and a recent study found fear recognition deficits in the absence of other emotion-recognition impairments, including disgust. To further examine emotion recognition in HD, we administered a computerized facial emotion recognition task to 475 individuals with the HD CAG expansion and 57 individuals without. Logistic regression was used to examine associations of emotion recognition performance with estimated proximity to clinical diagnosis (based on CAG repeat length and current age) and striatal volumes. Recognition of anger, disgust, fear, sadness and surprise (but not happiness) was associated with estimated years to clinical diagnosis; performance was unrelated to striatal volumes. Compared to a CAG-normal control group, the CAG-expanded group demonstrated significantly less accurate recognition of all negative emotions (anger, disgust, fear, sadness). Additionally, participants with more pronounced motor signs of HD were significantly less accurate at recognizing negative emotions than were individuals with fewer motor signs. Findings indicate that recognition of all negative emotions declines early in the disease process, and poorer performance is associated with closer proximity to clinical diagnosis. In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.

KW - Disgust

KW - Emotion recognition

KW - Predict-HD

KW - Presymptomatic Huntington's disease

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=34447620858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447620858&partnerID=8YFLogxK

U2 - 10.1093/brain/awm107

DO - 10.1093/brain/awm107

M3 - Article

C2 - 17584778

AN - SCOPUS:34447620858

VL - 130

SP - 1732

EP - 1744

JO - Brain

JF - Brain

SN - 0006-8950

IS - 7

ER -