Beyond C4d: Other Complement-Related Diagnostic Approaches to Antibody-Mediated Rejection

William M. Baldwin, Edward K. Kasper, Andrea A. Zachary, Barbara A. Wasowska, E. Rene Rodriguez

Research output: Contribution to journalShort survey

Abstract

Complement is a multifunctional system of receptors and regulators as well as effector molecules. Both the pathogenic and diagnostic power of complement is based on the capacity of the complement system to amplify innate and adaptive immunity. This amplification is accomplished through two strategies: (1) enzymatic reactions in the complement cascade, and (2) stimulation of leukocytes, platelets and parenchymal cells through specific receptors or receptor-independent pore formation. The mechanisms by which complement mediates and modifies nonspecific inflammation, antibody-mediated injury and T-cell responses are of particular significance to the pathogenesis of transplant rejection. Understanding the mechanisms by which complement integrates the interactions of leukocytes, platelets and parenchymal cells offers opportunities to further refine the diagnosis of rejection.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalAmerican Journal of Transplantation
Volume4
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • Antibodies
  • Complement
  • Complement receptors
  • Transplant rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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